OpenClaim

Becaplermin Side Effects

The most commonly reported side effects of becaplermin include off label use, wound complication, and application site pain, based on 2,141 FDA adverse event reports from 2004 to 2025. 9.0% of reports found the drug to be ineffective.

Becaplermin side effects

Percentages show how often each reaction appears relative to total reports for becaplermin.

1
Off Label Use31.6%676
2
Wound Complication21.0%449
3
Application Site Pain14.6%313
4
Drug Ineffective9.0%193
5
Inappropriate Schedule Of Drug Administration7.9%169
6
Osteomyelitis7.7%164
7
Incorrect Drug Administration Duration5.6%119
8
Wound Infection5.4%115
9
Toe Amputation5.0%106
10
Application Site Erythema4.8%102
11
Application Site Infection4.5%96
12
Wound Secretion4.0%86
13
Cellulitis3.8%82
14
Drug Ineffective For Unapproved Indication3.7%80
15
Application Site Discolouration3.5%74

These are voluntary reports and do not establish that becaplermin caused these reactions.

Report severity

41.6%Serious891 reports
23.8%Hospitalizations509 reports
3.8%Fatal81 reports

Seriousness is determined by the reporter, not by OpenClaim.

Becaplermin drug interactions

Other drugs that appear in adverse event reports alongside becaplermin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Collagenase1.7%37
2
Esomeprazole0.5%10
3
Omeprazole0.4%9
4
Gabapentin0.3%6
5
Silver-sulfadiazine0.3%6
6
Lansoprazole0.3%6
7
Pantoprazole-sodium0.3%6
8
Insulin0.2%5
9
Mupirocin0.2%5
10
Gadopentetate-dimeglumine0.2%4
11
Gadodiamide0.2%4
12
Gadoversetamide0.2%4
13
Gadoteridol0.2%4
14
Gadobenate-dimeglumine0.2%4
15
Prednisone0.2%4

Taken alongside

1
Insulin18.3%391
2
Aspirin13.9%297
3
Metformin13.4%286
4
Gabapentin10.0%214
5
Lisinopril9.3%200
6
Atorvastatin-calcium7.9%170
7
Furosemide7.7%164
8
Metoprolol7.2%155
9
Ergocalciferol7.1%153
10
Amlodipine5.7%122
11
Levothyroxine-sodium5.4%115
12
Acetaminophen5.2%112
13
Carvedilol5.0%107
14
Clopidogrel-bisulfate4.4%94
15
Omeprazole4.3%93

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports becaplermin side effects

39.4% of becaplermin adverse event reports involve female patients and 59.5% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.4%
Male59.5%
Unknown1.1%

Age group

< 20.2%
2–110.3%
12–170.2%
18–6451.8%
65+47.6%

What is becaplermin used for

Conditions and purposes for which patients were taking becaplermin when the adverse event was reported.

BlisterBlister InfectedCalcinosisCellulitisDecubitus UlcerDiabetic FootDiabetic NeuropathyDiabetic UlcerDiabetic WoundDrug IneffectiveDrug Use For Unknown IndicationDry SkinDiabetic UlcerErythemaFoot Deformity

Showing 15 of 67 indications

Becaplermin brand names and reporting trend

Becaplermin is sold under the brand name Regranex.

Brand names

Regranex8

Quarterly reports (20042025)

2005201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking becaplermin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.