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Baricitinib Side Effects

The most commonly reported side effects of baricitinib include off label use, covid-19, and rheumatoid arthritis, based on 9,309 FDA adverse event reports from 2006 to 2025. 7.6% of reports found the drug to be ineffective.

Baricitinib side effects

Percentages show how often each reaction appears relative to total reports for baricitinib.

1
Drug Ineffective7.6%711
2
Off Label Use7.1%658
3
Covid-194.7%440
4
Rheumatoid Arthritis3.8%352
5
Pulmonary Embolism3.2%300
6
Pneumonia2.8%264
7
Headache2.7%253
8
Herpes Zoster2.6%238
9
Death2.6%238
10
Nausea2.4%227
11
Deep Vein Thrombosis2.3%216
12
Fatigue2.0%183
13
Weight Increased1.9%179
14
Arthralgia1.9%179
15
Therapy Interrupted1.9%179

These are voluntary reports and do not establish that baricitinib caused these reactions.

Report severity

68.8%Serious6,403 reports
32.5%Hospitalizations3,028 reports
9.4%Fatal876 reports

Seriousness is determined by the reporter, not by OpenClaim.

Baricitinib drug interactions

Other drugs that appear in adverse event reports alongside baricitinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate10.6%984
2
Tocilizumab6.4%596
3
Adalimumab4.9%457
4
Etanercept4.8%444
5
Abatacept4.4%410
6
Rituximab3.4%319
7
Tofacitinib3.3%305
8
Upadacitinib3.1%289
9
Remdesivir3.1%288
10
Leflunomide3.1%287
11
Dexamethasone3.1%284
12
Certolizumab-pegol2.8%262
13
Hydroxychloroquine-sulfate2.5%229
14
Prednisone2.4%220
15
Infliximab2.1%200

Taken alongside

1
Methotrexate6.7%622
2
Prednisolone5.1%474
3
Dexamethasone5.0%463
4
Remdesivir4.7%440
5
Prednisone4.5%423
6
Folic-acid3.3%303
7
Omeprazole2.7%250
8
Methylprednisolone2.6%239
9
Pantoprazole-sodium2.3%210
10
Acetaminophen2.3%210
11
Enoxaparin-sodium2.2%202
12
Leflunomide2.1%191
13
Atorvastatin-calcium2.0%186
14
Hydroxychloroquine-sulfate2.0%184
15
Aspirin2.0%182

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports baricitinib side effects

60.8% of baricitinib adverse event reports involve female patients and 29.7% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.8%
Male29.7%
Unknown9.5%

Age group

< 20.3%
2–111.5%
12–170.9%
18–6457.8%
65+39.4%

What is baricitinib used for

Conditions and purposes for which patients were taking baricitinib when the adverse event was reported.

Acute Kidney InjuryAicardi-goutieres SyndromeAnkylosing SpondylitisAntisynthetase SyndromeArthralgiaArthritisArthropathyAutoimmune ArthritisAutoimmune DisorderAutoinflammatory DiseaseAcneAcute Respiratory Distress SyndromeAcute Respiratory FailureAdenosine Deaminase 2 DeficiencyAdverse Drug Reaction

Showing 15 of 229 indications

Baricitinib brand names and reporting trend

Baricitinib is sold under the brand name Baricitinib.

Brand names

Baricitinib3,234

Quarterly reports (20062025)

200620202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking baricitinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.