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Axitinib Side Effects

The most commonly reported side effects of axitinib include death, diarrhoea, and fatigue, based on 19,006 FDA adverse event reports from 2008 to 2025.

Axitinib side effects

Percentages show how often each reaction appears relative to total reports for axitinib.

1
Death13.6%2,578
2
Diarrhoea13.3%2,535
3
Fatigue10.9%2,080
4
Neoplasm Progression7.0%1,323
5
Hypertension6.9%1,306
6
Disease Progression6.2%1,181
7
Off Label Use6.2%1,178
8
Nausea5.9%1,124
9
Decreased Appetite5.6%1,065
10
Dysphonia5.3%1,004
11
Blood Pressure Increased4.4%835
12
Weight Decreased4.1%787
13
Asthenia3.9%745
14
Headache3.1%592
15
Stomatitis3.0%578

These are voluntary reports and do not establish that axitinib caused these reactions.

Report severity

65.7%Serious12,495 reports
25.7%Hospitalizations4,890 reports
20.1%Fatal3,825 reports

Seriousness is determined by the reporter, not by OpenClaim.

Axitinib drug interactions

Other drugs that appear in adverse event reports alongside axitinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pembrolizumab13.1%2,489
2
Avelumab4.2%798
3
Cabozantinib1.9%365
4
Nivolumab1.9%358
5
Sunitinib-malate1.2%226
6
Pazopanib-hydrochloride0.9%178
7
Everolimus0.8%153
8
Ipilimumab0.7%129
9
Lenvatinib-mesylate0.4%79
10
Denosumab0.4%68
11
Bevacizumab0.3%65
12
Zoledronic-acid0.3%61
13
Sorafenib-tosylate0.3%57
14
Apixaban0.3%56
15
Fluorouracil0.3%53

Taken alongside

1
Levothyroxine-sodium6.2%1,179
2
Amlodipine6.1%1,156
3
Pembrolizumab5.6%1,064
4
Acetaminophen4.9%931
5
Aspirin3.8%728
6
Atorvastatin-calcium3.5%658
7
Metoprolol3.1%581
8
Lisinopril2.9%557
9
Ondansetron2.9%553
10
Oxycodone2.9%551
11
Ergocalciferol2.8%539
12
Omeprazole2.7%510
13
Metformin2.1%398
14
Furosemide1.9%365
15
Losartan-potassium1.8%347

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports axitinib side effects

27.0% of axitinib adverse event reports involve female patients and 65.3% involve male patients. The largest age group is elderly at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female27.0%
Male65.3%
Unknown7.7%

Age group

< 2<0.1%
2–11<0.1%
12–170.2%
18–6444.9%
65+54.8%

What is axitinib used for

Conditions and purposes for which patients were taking axitinib when the adverse event was reported.

Acute Lymphocytic LeukaemiaAdenocarcinoma Of ColonAdenoid Cystic CarcinomaAdenoid Cystic Carcinoma Of Salivary GlandAdrenal CarcinomaAdrenal DisorderAdrenal Gland CancerAdrenal NeoplasmAdrenocortical CarcinomaAlveolar Soft Part SarcomaAlveolar Soft Part Sarcoma MetastaticAnaemiaAngiosarcomaAcute Kidney InjuryAcute Myeloid Leukaemia

Showing 15 of 442 indications

Axitinib brand names and reporting trend

Axitinib is sold under the brand name Axitinib.

Brand names

Axitinib4,176

Quarterly reports (20082025)

2010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking axitinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.