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Avutometinib Side Effects

The most commonly reported side effects of avutometinib include nausea, fatigue, and off label use, based on 298 FDA adverse event reports from 2005 to 2025.

Avutometinib side effects

Percentages show how often each reaction appears relative to total reports for avutometinib.

1
Nausea17.8%53
2
Fatigue14.8%44
3
Off Label Use13.1%39
4
Diarrhoea9.7%29
5
Rash9.1%27
6
Vomiting9.1%27
7
Vision Blurred7.7%23
8
Peripheral Swelling7.0%21
9
Product Dose Omission Issue6.7%20
10
Blood Creatine Phosphokinase Increased4.7%14
11
Pruritus4.7%14
12
Acne4.4%13
13
Visual Impairment4.4%13
14
Dizziness4.4%13
15
Dry Skin4.0%12

These are voluntary reports and do not establish that avutometinib caused these reactions.

Report severity

17.1%Serious51 reports
13.4%Hospitalizations40 reports
2.3%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Avutometinib drug interactions

Other drugs that appear in adverse event reports alongside avutometinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Defactinib-hydrochloride97.0%289
2
Sotorasib2.0%6
3
Bevacizumab0.7%2
4
Adalimumab0.3%1
5
Gemcitabine0.3%1
6
Paclitaxel0.3%1
7
Doxycycline0.3%1
8
Ondansetron0.3%1

Taken alongside

1
Ondansetron37.6%112
2
Doxycycline20.8%62
3
Acetaminophen18.8%56
4
Hydrocortisone15.4%46
5
Levothyroxine-sodium14.8%44
6
Ergocalciferol14.4%43
7
Apixaban12.1%36
8
Prochlorperazine11.4%34
9
Furosemide10.4%31
10
Rosuvastatin10.1%30
11
Oxycodone9.4%28
12
Aspirin8.7%26
13
Letrozole8.4%25
14
Loperamide-hydrochloride8.4%25
15
Amlodipine8.1%24

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports avutometinib side effects

2.0% of avutometinib adverse event reports involve female patients and 1.0% involve male patients. The largest age group is adult at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female2.0%
Male1.0%
Unknown97.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6480.0%
65+20.0%

What is avutometinib used for

Conditions and purposes for which patients were taking avutometinib when the adverse event was reported.

Blood Creatine Phosphokinase IncreasedBone CancerColon CancerDisease SusceptibilityGenital Neoplasm Malignant FemaleLung Carcinoma Cell Type Unspecified Stage ILung Neoplasm MalignantMalignant Peritoneal NeoplasmMetastases To LiverMetastases To LungMetastases To The MediastinumNon-small Cell Lung CancerOvarian CancerOvarian Cancer RecurrentPancreatic Carcinoma

Showing 15 of 20 indications

Avutometinib brand names and reporting trend

Avutometinib is sold under the brand name Avmapki Fakzynja Co-pack (copackaged).

Brand names

Avmapki Fakzynja Co-pack (copackaged)14

Quarterly reports (20052025)

20052025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking avutometinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.