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Avatrombopag Side Effects

The most commonly reported side effects of avatrombopag include platelet count decreased, headache, and platelet count increased, based on 2,196 FDA adverse event reports from 2006 to 2025. 13.1% of reports found the drug to be ineffective.

Avatrombopag side effects

Percentages show how often each reaction appears relative to total reports for avatrombopag.

1
Platelet Count Decreased14.8%325
2
Drug Ineffective13.1%287
3
Headache9.3%204
4
Platelet Count Increased8.3%183
5
Fatigue7.0%154
6
Off Label Use6.8%149
7
Platelet Count Abnormal4.8%105
8
Nausea4.6%101
9
Death4.1%91
10
Product Dose Omission Issue3.9%86
11
Inappropriate Schedule Of Product Administration3.6%78
12
Diarrhoea3.5%76
13
Arthralgia3.0%66
14
Dizziness2.8%61
15
Asthenia2.6%57

These are voluntary reports and do not establish that avatrombopag caused these reactions.

Report severity

41.6%Serious913 reports
19.6%Hospitalizations430 reports
6.9%Fatal151 reports

Seriousness is determined by the reporter, not by OpenClaim.

Avatrombopag drug interactions

Other drugs that appear in adverse event reports alongside avatrombopag. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Fostamatinib-disodium5.8%128
2
Rituximab2.6%58
3
Romiplostim2.4%53
4
Eltrombopag2.0%44
5
Dexamethasone1.8%39
6
Mycophenolate1.3%28
7
Prednisone1.2%27
8
Pomalidomide1.1%25
9
Isatuximab-irfc0.9%20
10
Cyclosporine0.7%15
11
Vincristine-sulfate0.6%13
12
Prednisolone0.5%11
13
Cyclophosphamide0.5%11
14
Atezolizumab0.5%10
15
Pegcetacoplan0.5%10

Taken alongside

1
Prednisone4.2%92
2
Ergocalciferol3.6%79
3
Pantoprazole-sodium3.6%79
4
Eltrombopag3.3%72
5
Acetaminophen3.2%70
6
Dexamethasone3.1%69
7
Omeprazole2.7%60
8
Levothyroxine-sodium2.6%56
9
Metformin2.4%52
10
Furosemide2.3%50
11
Metoprolol2.3%50
12
Amlodipine2.3%50
13
Losartan-potassium2.1%47
14
Cyanocobalamin2.0%45
15
Romiplostim1.9%42

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports avatrombopag side effects

54.9% of avatrombopag adverse event reports involve female patients and 37.9% involve male patients. The largest age group is adult at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.9%
Male37.9%
Unknown7.2%

Age group

< 20.1%
2–111.0%
12–171.5%
18–6448.7%
65+48.7%

What is avatrombopag used for

Conditions and purposes for which patients were taking avatrombopag when the adverse event was reported.

Acute Myeloid LeukaemiaAnaemiaAnaemia Of Chronic DiseaseAnal CancerAplastic AnaemiaArterial ThrombosisAcute Myeloid LeukaemiaAdenomyosisAdverse Drug ReactionAnaemiaAnaemia Folate DeficiencyAplastic AnaemiaArthropathyAscitesAutoimmune Haemolytic Anaemia

Showing 15 of 153 indications

Avatrombopag brand names and reporting trend

Avatrombopag is sold under the brand name Doptelet.

Brand names

Doptelet443

Quarterly reports (20062025)

200620202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking avatrombopag with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.