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Avapritinib Side Effects

The most commonly reported side effects of avapritinib include fatigue, off label use, and nausea, based on 10,789 FDA adverse event reports from 2019 to 2025.

Avapritinib side effects

Percentages show how often each reaction appears relative to total reports for avapritinib.

1
Fatigue14.8%1,594
2
Off Label Use11.3%1,218
3
Nausea10.2%1,104
4
Diarrhoea8.7%937
5
Swelling Face4.6%498
6
Dizziness4.6%492
7
Memory Impairment4.5%490
8
Headache4.5%489
9
Vomiting4.5%482
10
Asthenia4.1%443
11
Platelet Count Decreased4.1%437
12
Peripheral Swelling4.0%434
13
Rash4.0%431
14
Lacrimation Increased3.8%413
15
Product Dose Omission Issue3.7%403

These are voluntary reports and do not establish that avapritinib caused these reactions.

Report severity

28.9%Serious3,115 reports
9.5%Hospitalizations1,024 reports
3.0%Fatal327 reports

Seriousness is determined by the reporter, not by OpenClaim.

Avapritinib drug interactions

Other drugs that appear in adverse event reports alongside avapritinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sunitinib-malate0.4%43
2
Ripretinib0.3%35
3
Imatinib-mesylate0.2%21
4
Midostaurin0.2%19
5
Ondansetron0.2%19
6
Metoprolol0.2%19
7
Prednisone0.2%17
8
Duloxetine-hydrochloride0.2%17
9
Gabapentin0.1%16
10
Azacitidine0.1%15
11
Diphenhydramine0.1%15
12
Sertraline-hydrochloride0.1%13
13
Omalizumab0.1%13
14
Olanzapine0.1%13
15
Oxycodone0.1%12

Taken alongside

1
Ondansetron5.8%631
2
Famotidine5.4%588
3
Ergocalciferol3.9%417
4
Cetirizine-hydrochloride3.7%397
5
Montelukast-sodium3.2%344
6
Omeprazole2.9%309
7
Epinephrine2.7%287
8
Acetaminophen2.6%283
9
Pantoprazole-sodium2.5%274
10
Levothyroxine-sodium2.5%266
11
Cromolyn-sodium2.0%217
12
Albuterol2.0%216
13
Aspirin2.0%214
14
Amlodipine2.0%213
15
Atorvastatin-calcium1.9%209

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports avapritinib side effects

54.3% of avapritinib adverse event reports involve female patients and 40.8% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.3%
Male40.8%
Unknown4.9%

Age group

< 2<0.1%
2–111.1%
12–170.7%
18–6448.0%
65+50.1%

What is avapritinib used for

Conditions and purposes for which patients were taking avapritinib when the adverse event was reported.

Acute Myeloid LeukaemiaAbdominal MassAbdominal NeoplasmAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RefractoryAcute Myelomonocytic LeukaemiaAdvanced Systemic MastocytosisAnaemiaAnal CancerAnaphylactic ReactionAnaplastic Lymphoma Kinase Gene MutationAstrocytomaBrain Neoplasm Malignant

Showing 15 of 158 indications

Avapritinib brand names and reporting trend

Avapritinib is sold under the brand name Ayvakit.

Brand names

Ayvakit752

Quarterly reports (20192025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking avapritinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.