OpenClaim

Avalglucosidase Side Effects

The most commonly reported side effects of avalglucosidase include drug specific antibody present, off label use, and weight increased, based on 827 FDA adverse event reports from 2012 to 2025.

Avalglucosidase side effects

Percentages show how often each reaction appears relative to total reports for avalglucosidase.

1
Drug Specific Antibody Present15.4%127
2
Off Label Use9.9%82
3
Weight Increased5.9%49
4
Weight Decreased4.4%36
5
Fatigue3.9%32
6
Inappropriate Schedule Of Product Administration3.9%32
7
Dyspnoea3.6%30
8
Pyrexia3.4%28
9
Condition Aggravated3.1%26
10
Illness2.9%24
11
Headache2.8%23
12
Pruritus2.5%21
13
Product Preparation Error2.5%21
14
Malaise2.4%20
15
Cough2.3%19

These are voluntary reports and do not establish that avalglucosidase caused these reactions.

Report severity

21.2%Serious175 reports
11.1%Hospitalizations92 reports
1.0%Fatal8 reports

Seriousness is determined by the reporter, not by OpenClaim.

Avalglucosidase drug interactions

Other drugs that appear in adverse event reports alongside avalglucosidase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Prednisone0.6%5
2
Tacrolimus0.5%4
3
Diphenhydramine0.5%4
4
Methotrexate0.5%4
5
Etanercept0.4%3
6
Mycophenolate0.4%3
7
Methylprednisolone0.4%3
8
Basiliximab0.4%3
9
Bosentan0.2%2
10
Glatiramer-acetate0.2%2
11
Enzalutamide0.2%2
12
Lidocaine0.2%2
13
Leuprolide0.2%2
14
Prednisolone0.1%1
15
Interferon0.1%1

Taken alongside

1
Dextrose15.7%130
2
Sodium-chloride14.9%123
3
Sterile14.8%122
4
Epinephrine13.4%111
5
Diphenhydramine13.4%111
6
Acetaminophen12.7%105
7
Heparin6.7%55
8
Methylprednisolone5.3%44
9
Cetirizine-hydrochloride5.2%43
10
Ergocalciferol5.1%42
11
Ibuprofen4.6%38
12
Lidocaine2.7%22
13
Famotidine2.7%22
14
Losartan-potassium2.3%19
15
Pregabalin2.2%18

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports avalglucosidase side effects

46.4% of avalglucosidase adverse event reports involve female patients and 40.5% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.4%
Male40.5%
Unknown13.1%

Age group

< 22.6%
2–1117.0%
12–175.1%
18–6462.5%
65+12.8%

What is avalglucosidase used for

Conditions and purposes for which patients were taking avalglucosidase when the adverse event was reported.

Blood Galactose AbnormalCovid-19ConstipationElectrolyte Substitution TherapyGeneral Physical ConditionGlycogen Storage Disease Type IiGalactosaemiaGlycogen Storage Disease Type IiGlycogen Storage DisorderHypoglycaemiaHypoglycaemiaImmune System DisorderMetabolic DisorderObstructive Sleep Apnoea SyndromeProduct Used For Unknown Indication

Showing 15 of 19 indications

Avalglucosidase brand names and reporting trend

Avalglucosidase is sold under the brand name Nexviazyme.

Brand names

Nexviazyme111

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking avalglucosidase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.