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Avacopan Side Effects

The most commonly reported side effects of avacopan include hospitalisation, off label use, and death, based on 5,094 FDA adverse event reports from 2021 to 2025. 2.5% of reports found the drug to be ineffective.

Avacopan side effects

Percentages show how often each reaction appears relative to total reports for avacopan.

1
Hospitalisation12.3%627
2
Off Label Use6.3%319
3
Death5.8%297
4
Fatigue4.4%226
5
Diarrhoea4.4%224
6
Nausea4.2%213
7
Pneumonia3.2%165
8
Headache3.2%163
9
Covid-193.0%154
10
Product Dose Omission Issue2.9%146
11
Therapy Interrupted2.9%146
12
Drug Ineffective2.5%126
13
Dyspnoea2.2%110
14
Infection2.1%108
15
Rash2.0%104

These are voluntary reports and do not establish that avacopan caused these reactions.

Report severity

67.9%Serious3,457 reports
38.6%Hospitalizations1,966 reports
10.2%Fatal518 reports

Seriousness is determined by the reporter, not by OpenClaim.

Avacopan drug interactions

Other drugs that appear in adverse event reports alongside avacopan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab5.9%298
2
Prednisone3.7%186
3
Prednisolone1.9%95
4
Cyclophosphamide1.5%75
5
Methylprednisolone0.8%40
6
Azathioprine0.6%31
7
Methotrexate0.5%28
8
Mycophenolate0.5%24
9
Sulfamethoxazole0.3%15
10
Trimethoprim0.3%15
11
Ganciclovir0.2%12
12
Amlodipine0.2%11
13
Ciprofloxacin0.2%11
14
Leflunomide0.2%9
15
Methoxy-polyethylene-glycol-epoetin-beta0.2%8

Taken alongside

1
Rituximab10.7%547
2
Prednisolone8.2%418
3
Prednisone6.8%346
4
Cyclophosphamide3.9%198
5
Amlodipine3.6%182
6
Methylprednisolone3.2%165
7
Atorvastatin-calcium2.2%114
8
Sulfamethoxazole1.8%90
9
Trimethoprim1.7%88
10
Omeprazole1.7%87
11
Furosemide1.7%86
12
Vonoprazan-fumarate1.6%81
13
Azathioprine1.6%79
14
Pantoprazole-sodium1.5%77
15
Lansoprazole1.5%76

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports avacopan side effects

41.4% of avacopan adverse event reports involve female patients and 32.7% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female41.4%
Male32.7%
Unknown26.0%

Age group

< 20.3%
2–110.3%
12–170.7%
18–6443.1%
65+55.6%

What is avacopan used for

Conditions and purposes for which patients were taking avacopan when the adverse event was reported.

Acute Kidney InjuryAngiopathyAnkylosing SpondylitisAnti-neutrophil Cytoplasmic Antibody Positive VasculitisAntineutrophil Cytoplasmic AntibodyAntineutrophil Cytoplasmic Antibody IncreasedAntineutrophil Cytoplasmic Antibody NegativeAntineutrophil Cytoplasmic Antibody PositiveArterial DisorderArteritisArthralgiaArthritisAutism Spectrum DisorderAutoimmune DisorderAutoimmune Vasculitis

Showing 15 of 87 indications

Avacopan brand names and reporting trend

Avacopan is sold under the brand name Tavneos.

Brand names

Tavneos743

Quarterly reports (20212025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking avacopan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.