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Atropine Side Effects

The most commonly reported side effects of atropine include diarrhoea, nausea, and fatigue, based on 28,244 FDA adverse event reports from 2004 to 2025. 7.1% of reports found the drug to be ineffective.

Atropine side effects

Percentages show how often each reaction appears relative to total reports for atropine.

1
Diarrhoea11.2%3,162
2
Nausea7.1%1,995
3
Drug Ineffective7.1%1,993
4
Fatigue6.8%1,910
5
Off Label Use5.6%1,569
6
Death4.2%1,177
7
Vomiting4.1%1,168
8
Pain3.9%1,110
9
Weight Decreased3.7%1,037
10
Dyspnoea3.5%993
11
Headache3.2%899
12
Abdominal Pain3.2%892
13
Asthenia3.0%861
14
Decreased Appetite3.0%839
15
Pyrexia2.9%821

These are voluntary reports and do not establish that atropine caused these reactions.

Report severity

76.6%Serious21,630 reports
39.8%Hospitalizations11,232 reports
14.1%Fatal3,986 reports

Seriousness is determined by the reporter, not by OpenClaim.

Atropine drug interactions

Other drugs that appear in adverse event reports alongside atropine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab6.7%1,884
2
Lenalidomide6.4%1,804
3
Irinotecan-hydrochloride5.8%1,642
4
Bevacizumab3.5%994
5
Fluorouracil3.5%983
6
Diphenoxylate-hydrochloride3.5%975
7
Acetaminophen3.1%865
8
Fentanyl2.7%757
9
Clozapine2.5%719
10
Dexamethasone2.4%672
11
Prednisone2.2%634
12
Pantoprazole-sodium2.2%625
13
Propofol2.2%609
14
Oxaliplatin2.1%584
15
Pomalidomide2.0%551

Taken alongside

1
Diphenoxylate-hydrochloride48.2%13,615
2
Acetaminophen22.6%6,390
3
Ondansetron19.0%5,369
4
Ergocalciferol14.1%3,975
5
Aspirin13.7%3,873
6
Dexamethasone13.1%3,694
7
Omeprazole12.2%3,457
8
Loperamide-hydrochloride12.1%3,419
9
Levothyroxine-sodium12.1%3,410
10
Furosemide11.5%3,246
11
Gabapentin10.8%3,060
12
Pantoprazole-sodium10.6%2,988
13
Lorazepam10.2%2,876
14
Albuterol9.6%2,707
15
Oxycodone9.3%2,619

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports atropine side effects

52.8% of atropine adverse event reports involve female patients and 39.6% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.8%
Male39.6%
Unknown7.7%

Age group

< 22.1%
2–112.4%
12–171.8%
18–6451.9%
65+41.8%

What is atropine used for

Conditions and purposes for which patients were taking atropine when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAbdominal Pain UpperAbdominal RigidityAbnormal BehaviourAbnormal FaecesAcanthamoeba InfectionAcanthamoeba KeratitisAccidentAccidental Drug Intake By ChildAcute Coronary SyndromeAcute Myeloid LeukaemiaAcute Myocardial InfarctionAcute PsychosisAcute Pulmonary Oedema

Showing 15 of 876 indications

Atropine brand names and reporting trend

Atropine is sold under brand names including Atropine (autoinjector), Logen.

Brand names

Atropine (autoinjector)11,995
Logen3,445

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking atropine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.