OpenClaim

Atovaquone Side Effects

The most commonly reported side effects of atovaquone include off label use, nausea, and diarrhoea, based on 10,570 FDA adverse event reports from 2004 to 2025. 4.0% of reports found the drug to be ineffective.

Atovaquone side effects

Percentages show how often each reaction appears relative to total reports for atovaquone.

1
Off Label Use7.5%797
2
Nausea4.4%460
3
Diarrhoea4.3%450
4
Pyrexia4.1%434
5
Drug Ineffective4.0%428
6
Pneumonia3.9%414
7
Vomiting3.1%329
8
Fatigue3.0%321
9
Condition Aggravated2.9%311
10
Death2.9%310
11
Dyspnoea2.8%299
12
Acute Kidney Injury2.6%278
13
Rash2.6%275
14
Thrombocytopenia2.4%249
15
Headache2.2%233

These are voluntary reports and do not establish that atovaquone caused these reactions.

Report severity

83.6%Serious8,838 reports
46.8%Hospitalizations4,946 reports
13.6%Fatal1,438 reports

Seriousness is determined by the reporter, not by OpenClaim.

Atovaquone drug interactions

Other drugs that appear in adverse event reports alongside atovaquone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Proguanil-hydrochloride17.5%1,849
2
Lenalidomide6.5%691
3
Prednisone6.1%648
4
Tacrolimus5.9%626
5
Rituximab5.4%566
6
Cyclophosphamide4.8%506
7
Mycophenolate4.7%502
8
Dexamethasone4.3%458
9
Acyclovir3.9%408
10
Azithromycin3.5%366
11
Tenofovir2.8%294
12
Methotrexate2.6%280
13
Sulfamethoxazole2.6%275
14
Methylprednisolone2.6%272
15
Trimethoprim2.4%257

Taken alongside

1
Acyclovir21.9%2,317
2
Prednisone15.4%1,623
3
Acetaminophen12.0%1,264
4
Pantoprazole-sodium10.3%1,084
5
Ondansetron9.0%951
6
Ergocalciferol8.3%874
7
Amlodipine8.0%844
8
Aspirin7.7%816
9
Omeprazole7.7%811
10
Furosemide7.4%782
11
Dexamethasone6.8%721
12
Levothyroxine-sodium6.8%715
13
Azithromycin6.7%713
14
Tacrolimus6.4%681
15
Fluconazole6.1%642

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports atovaquone side effects

42.4% of atovaquone adverse event reports involve female patients and 45.2% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.4%
Male45.2%
Unknown12.4%

Age group

< 21.3%
2–111.6%
12–171.9%
18–6461.8%
65+33.4%

What is atovaquone used for

Conditions and purposes for which patients were taking atovaquone when the adverse event was reported.

Abo IncompatibilityAids Related ComplicationAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyAntifungal ProphylaxisAntifungal TreatmentAntiviral ProphylaxisAntiviral TreatmentAnxietyAnxiety DisorderAplastic AnaemiaArthropod BiteAspergillus InfectionAtrial Fibrillation

Showing 15 of 278 indications

Atovaquone brand names and reporting trend

Atovaquone is sold under the brand name Malarone.

Brand names

Malarone7,198

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking atovaquone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.