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Atezolizumab Side Effects

The most commonly reported side effects of atezolizumab include death, off label use, and disease progression, based on 36,571 FDA adverse event reports from 2004 to 2025.

Atezolizumab side effects

Percentages show how often each reaction appears relative to total reports for atezolizumab.

1
Death11.1%4,053
2
Off Label Use8.9%3,261
3
Disease Progression5.5%1,999
4
Pyrexia4.6%1,692
5
Diarrhoea4.5%1,632
6
Fatigue3.8%1,393
7
Anaemia3.5%1,274
8
Pneumonia3.0%1,083
9
Decreased Appetite2.8%1,031
10
Nausea2.7%1,005
11
Dyspnoea2.7%987
12
Hypothyroidism2.7%976
13
Hypertension2.5%920
14
Febrile Neutropenia2.5%914
15
Pneumonitis2.5%910

These are voluntary reports and do not establish that atezolizumab caused these reactions.

Report severity

95.3%Serious34,866 reports
43.4%Hospitalizations15,863 reports
25.5%Fatal9,343 reports

Seriousness is determined by the reporter, not by OpenClaim.

Atezolizumab drug interactions

Other drugs that appear in adverse event reports alongside atezolizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bevacizumab38.7%14,166
2
Carboplatin18.5%6,751
3
Paclitaxel12.2%4,450
4
Etoposide8.1%2,965
5
Pemetrexed2.5%921
6
Cisplatin2.2%811
7
Cobimetinib-fumarate2.0%732
8
Gemcitabine1.8%658
9
Cabozantinib1.7%608
10
Pembrolizumab1.6%579
11
Doxorubicin-hydrochloride1.5%551
12
Trastuzumab1.4%505
13
Oxaliplatin1.3%489
14
Cyclophosphamide1.3%485
15
Nivolumab1.3%482

Taken alongside

1
Acetaminophen7.9%2,884
2
Carboplatin6.8%2,488
3
Ondansetron5.5%1,998
4
Dexamethasone5.3%1,946
5
Omeprazole5.2%1,911
6
Amlodipine4.6%1,689
7
Paclitaxel4.4%1,607
8
Pantoprazole-sodium4.0%1,447
9
Levothyroxine-sodium3.8%1,393
10
Furosemide3.4%1,241
11
Metformin3.3%1,211
12
Metoclopramide-hydrochloride3.1%1,140
13
Atorvastatin-calcium3.1%1,137
14
Aspirin3.1%1,123
15
Oxycodone2.9%1,077

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports atezolizumab side effects

31.7% of atezolizumab adverse event reports involve female patients and 52.4% involve male patients. The largest age group is elderly at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female31.7%
Male52.4%
Unknown16.0%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6441.9%
65+58.0%

What is atezolizumab used for

Conditions and purposes for which patients were taking atezolizumab when the adverse event was reported.

Acute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma Of AppendixAdenocarcinoma Of ColonAdenocarcinoma Of Salivary GlandAdenocarcinoma Of The CervixAdenocarcinoma PancreasAdenosquamous Cell Lung CancerAgranulocytosisAlk Gene Rearrangement PositiveAlveolar Soft Part SarcomaAlveolar Soft Part Sarcoma MetastaticAnaemiaAnal Cancer

Showing 15 of 798 indications

Atezolizumab brand names and reporting trend

Atezolizumab is sold under brand names including Tecentriq, Tecentriq Hybreza.

Brand names

Tecentriq27,319
Tecentriq Hybreza7

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking atezolizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.