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Asfotase Side Effects

The most commonly reported side effects of asfotase include injection site pain, injection site erythema, and fatigue, based on 9,112 FDA adverse event reports from 2014 to 2025. 2.6% of reports found the drug to be ineffective.

Asfotase side effects

Percentages show how often each reaction appears relative to total reports for asfotase.

1
Injection Site Pain13.8%1,254
2
Injection Site Erythema9.1%833
3
Fatigue8.9%809
4
Pain7.7%705
5
Injection Site Reaction7.4%674
6
Arthralgia6.2%569
7
Pain In Extremity5.3%487
8
Injection Site Bruising5.2%470
9
Injection Site Swelling4.6%422
10
Headache3.8%344
11
Injection Site Pruritus3.5%320
12
Injection Site Mass3.1%284
13
Blood Alkaline Phosphatase Increased3.1%284
14
Nausea3.0%275
15
Malaise3.0%274

These are voluntary reports and do not establish that asfotase caused these reactions.

Report severity

26.4%Serious2,403 reports
6.9%Hospitalizations629 reports
0.7%Fatal66 reports

Seriousness is determined by the reporter, not by OpenClaim.

Asfotase drug interactions

Other drugs that appear in adverse event reports alongside asfotase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Semaglutide<0.1%9
2
Diphenhydramine<0.1%8
3
Gabapentin<0.1%7
4
Teriparatide<0.1%5
5
Duloxetine-hydrochloride<0.1%5
6
Ibuprofen<0.1%4
7
Adalimumab<0.1%4
8
Topiramate<0.1%4
9
Amoxicillin<0.1%3
10
Hydroxychloroquine-sulfate<0.1%3
11
Calcium<0.1%3
12
Prednisone<0.1%3
13
Dupilumab<0.1%3
14
Methotrexate<0.1%3
15
Levothyroxine-sodium<0.1%3

Taken alongside

1
Ergocalciferol0.9%79
2
Acetaminophen0.7%64
3
Ibuprofen0.5%50
4
Diphenhydramine0.4%40
5
Levothyroxine-sodium0.4%36
6
Calcium0.4%34
7
Gabapentin0.4%32
8
Cetirizine-hydrochloride0.3%31
9
Aspirin0.3%25
10
Omeprazole0.3%25
11
Prednisone0.3%25
12
Loratadine0.2%21
13
Budesonide0.2%21
14
Buspirone-hydrochloride0.2%21
15
Pyridoxine0.2%20

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports asfotase side effects

62.5% of asfotase adverse event reports involve female patients and 23.8% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female62.5%
Male23.8%
Unknown13.7%

Age group

< 26.5%
2–1116.0%
12–176.9%
18–6453.8%
65+16.7%

What is asfotase used for

Conditions and purposes for which patients were taking asfotase when the adverse event was reported.

Bone DisorderEnzyme AbnormalityEnzyme Level AbnormalHaemolytic Uraemic SyndromeHypophosphataemiaHypophosphatasiaHepatic Enzyme AbnormalHyperphosphataemiaHypophosphataemiaHypophosphatasiaInfection ParasiticIron Metabolism DisorderJuvenile Idiopathic ArthritisLysosomal Storage DisorderMultiple Congenital Abnormalities

Showing 15 of 25 indications

Asfotase brand names and reporting trend

Asfotase is sold under the brand name Strensiq.

Brand names

Strensiq75

Quarterly reports (20142025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking asfotase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.