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Ascorbic Side Effects

The most commonly reported side effects of ascorbic include fatigue, headache, and nausea, based on 124,154 FDA adverse event reports from 2004 to 2025. 6.8% of reports found the drug to be ineffective.

Ascorbic side effects

Percentages show how often each reaction appears relative to total reports for ascorbic.

1
Fatigue9.9%12,353
2
Headache7.2%8,926
3
Nausea7.2%8,923
4
Pain7.1%8,811
5
Diarrhoea7.1%8,761
6
Off Label Use6.8%8,494
7
Drug Ineffective6.8%8,454
8
Dyspnoea5.4%6,706
9
Arthralgia5.1%6,344
10
Dizziness5.0%6,179
11
Vomiting4.9%6,144
12
Rash4.9%6,130
13
Asthenia4.8%5,999
14
Pruritus4.0%4,933
15
Malaise3.7%4,624

These are voluntary reports and do not establish that ascorbic caused these reactions.

Report severity

61.3%Serious76,144 reports
29.5%Hospitalizations36,610 reports
8.6%Fatal10,725 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ascorbic drug interactions

Other drugs that appear in adverse event reports alongside ascorbic. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab7.3%9,063
2
Lenalidomide5.2%6,482
3
Etanercept5.2%6,411
4
Rituximab4.6%5,725
5
Abatacept4.5%5,637
6
Acetaminophen4.4%5,409
7
Tocilizumab4.3%5,375
8
Prednisone4.3%5,348
9
Methotrexate4.2%5,185
10
Infliximab4.0%4,951
11
Tofacitinib3.7%4,615
12
Certolizumab-pegol3.7%4,559
13
Cetirizine-hydrochloride3.6%4,490
14
Leflunomide3.6%4,480
15
Diclofenac3.6%4,419

Taken alongside

1
Ergocalciferol45.3%56,245
2
Aspirin22.9%28,425
3
Acetaminophen21.7%26,967
4
Calcium18.5%22,981
5
Cyanocobalamin18.1%22,451
6
Levothyroxine-sodium15.3%18,953
7
Folic-acid13.4%16,581
8
Fish13.3%16,527
9
Omeprazole12.8%15,889
10
Vitamin-e12.2%15,089
11
Albuterol11.8%14,636
12
Atorvastatin-calcium11.6%14,348
13
Furosemide10.7%13,247
14
Metoprolol10.5%13,046
15
Gabapentin10.1%12,592

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ascorbic side effects

62.5% of ascorbic adverse event reports involve female patients and 30.9% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female62.5%
Male30.9%
Unknown6.6%

Age group

< 20.3%
2–110.7%
12–171.0%
18–6450.8%
65+47.1%

What is ascorbic used for

Conditions and purposes for which patients were taking ascorbic when the adverse event was reported.

Abdominal DiscomfortAbdominal Pain UpperAcneAcquired Cystic Kidney DiseaseActinic KeratosisAcute Kidney InjuryAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAcute Respiratory FailureAdenocarcinoma GastricAdjuvant TherapyAdverse EventAffective DisorderAge-related Macular DegenerationAlbuminuria

Showing 15 of 1,012 indications

Ascorbic brand names and reporting trend

Ascorbic is sold under the brand name Plenvu.

Brand names

Plenvu123,536

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ascorbic with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.