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Asciminib Side Effects

The most commonly reported side effects of asciminib include fatigue, death, and nausea, based on 2,686 FDA adverse event reports from 2010 to 2025. 5.6% of reports found the drug to be ineffective.

#1 Reported: FatigueAll side effects ↓Top Co-Medication: Imatinib-mesylateDrug interactions ↓54% of Reports Are AdultDemographics ↓

Asciminib side effects

Percentages show how often each reaction appears relative to total reports for asciminib.

1
Fatigue8.1%218
2
Death5.9%158
3
Nausea5.8%157
4
Drug Ineffective5.6%151
5
Thrombocytopenia5.1%138
6
Diarrhoea4.4%118
7
Drug Intolerance4.3%115
8
Headache4.2%112
9
Rash3.6%98
10
Pleural Effusion3.3%88
11
Arthralgia3.2%85
12
Hypertension3.1%84
13
Cytopenia2.8%75
14
Malignant Neoplasm Progression2.8%74
15
Dyspnoea2.8%74

These are voluntary reports and do not establish that asciminib caused these reactions.

Report severity

67.3%Serious1,808 reports
18.2%Hospitalizations490 reports
11.4%Fatal305 reports

Seriousness is determined by the reporter, not by OpenClaim.

Asciminib drug interactions

Other drugs that appear in adverse event reports alongside asciminib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Imatinib-mesylate10.8%290
2
Nilotinib9.9%265
3
Dasatinib8.3%223
4
Ponatinib-hydrochloride4.4%119
5
Bosutinib-monohydrate3.7%100
6
Aspirin1.0%27
7
Hydroxyurea1.0%27
8
Prednisone1.0%26
9
Ruxolitinib1.0%26
10
Budesonide0.9%25
11
Allopurinol0.9%25
12
Atorvastatin-calcium0.8%22
13
Bisoprolol-fumarate0.8%22
14
Bumetanide0.8%21
15
Metformin0.7%20

Taken alongside

1
Aspirin2.2%59
2
Furosemide2.1%57
3
Amlodipine2.1%56
4
Allopurinol2.0%55
5
Atorvastatin-calcium1.9%52
6
Dasatinib1.8%48
7
Levothyroxine-sodium1.7%45
8
Metoprolol1.6%44
9
Pantoprazole-sodium1.6%42
10
Bisoprolol-fumarate1.4%37
11
Bosutinib-monohydrate1.3%36
12
Apixaban1.3%35
13
Ondansetron1.2%33
14
Albuterol1.2%33
15
Acyclovir1.2%32

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports asciminib side effects

40.2% of asciminib adverse event reports involve female patients and 39.7% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.2%
Male39.7%
Unknown20.1%

Age group

< 20.8%
2–11<0.1%
12–171.0%
18–6454.2%
65+44.0%

What is asciminib used for

Conditions and purposes for which patients were taking asciminib when the adverse event was reported.

Acute Lymphocytic LeukaemiaAsxl1 Gene MutationAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaB Precursor Type Acute LeukaemiaB-cell Small Lymphocytic LymphomaB-cell Type Acute LeukaemiaBlast Crisis In Myelogenous LeukaemiaBlood Pressure MeasurementChronic Myeloid LeukaemiaCardiac Failure CongestiveCerebral PalsyChloroma

Showing 15 of 65 indications

Asciminib brand names and reporting trend

Asciminib is sold under the brand name Scemblix.

Brand names

Scemblix1,064

Quarterly reports (2010–2025)

2010202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking asciminib with another medication?

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