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Aripiprazole Side Effects

The most commonly reported side effects of aripiprazole include off label use, weight increased, and product use in unapproved indication, based on 124,649 FDA adverse event reports from 2004 to 2025. 6.3% of reports found the drug to be ineffective.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: Quetiapine-fumarateDrug interactions ↓76% of Reports Are AdultDemographics ↓

Aripiprazole side effects

Percentages show how often each reaction appears relative to total reports for aripiprazole.

1
Off Label Use6.7%8,340
2
Drug Ineffective6.3%7,807
3
Weight Increased5.2%6,464
4
Product Use In Unapproved Indication4.2%5,292
5
Anxiety3.7%4,595
6
Fatigue3.1%3,897
7
Suicidal Ideation2.9%3,596
8
Depression2.8%3,502
9
Nausea2.7%3,417
10
Suicide Attempt2.6%3,263
11
Insomnia2.6%3,194
12
Drug Interaction2.6%3,181
13
Somnolence2.5%3,129
14
Condition Aggravated2.4%3,027
15
Tremor2.4%2,968

These are voluntary reports and do not establish that aripiprazole caused these reactions.

Report severity

65.1%Serious81,176 reports
28.9%Hospitalizations35,968 reports
5.4%Fatal6,788 reports

Seriousness is determined by the reporter, not by OpenClaim.

Aripiprazole drug interactions

Other drugs that appear in adverse event reports alongside aripiprazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate7.4%9,186
2
Olanzapine6.2%7,672
3
Risperidone5.5%6,830
4
Clozapine4.6%5,742
5
Sertraline-hydrochloride2.8%3,477
6
Lamotrigine2.5%3,116
7
Sodium-oxybate2.2%2,734
8
Fluoxetine-hydrochloride2.1%2,654
9
Haloperidol2.0%2,473
10
Venlafaxine1.9%2,393
11
Paliperidone1.8%2,275
12
Lithium1.8%2,273
13
Bupropion1.8%2,250
14
Lorazepam1.7%2,117
15
Duloxetine-hydrochloride1.7%2,102

Taken alongside

1
Clonazepam5.1%6,296
2
Acetaminophen4.6%5,783
3
Levothyroxine-sodium4.5%5,614
4
Sertraline-hydrochloride4.4%5,489
5
Lorazepam4.3%5,308
6
Bupropion4.2%5,263
7
Trazodone-hydrochloride4.1%5,142
8
Gabapentin4.0%5,041
9
Lamotrigine4.0%5,007
10
Duloxetine-hydrochloride4.0%5,002
11
Quetiapine-fumarate3.6%4,497
12
Ergocalciferol3.6%4,457
13
Omeprazole3.5%4,379
14
Metformin3.5%4,362
15
Albuterol3.5%4,321

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports aripiprazole side effects

50.8% of aripiprazole adverse event reports involve female patients and 35.6% involve male patients. The largest age group is adult at 76%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.8%
Male35.6%
Unknown13.6%

Age group

< 21.6%
2–114.1%
12–177.3%
18–6475.8%
65+11.1%

What is aripiprazole used for

Conditions and purposes for which patients were taking aripiprazole when the adverse event was reported.

Abdominal Pain UpperAbnormal BehaviourAbnormal DreamsAbuliaAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental PoisoningAcneAcute PsychosisAdjustment DisorderAdjustment Disorder With AnxietyAdjustment Disorder With Depressed MoodAdjustment Disorder With Mixed Anxiety And Depressed MoodAdjuvant Therapy

Showing 15 of 1,091 indications

Aripiprazole brand names and reporting trend

Aripiprazole is sold under brand names including Abilify Asimtufii, Aristada.

Brand names

Abilify Asimtufii52,997
Aristada424

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking aripiprazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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