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Argatroban Side Effects

The most commonly reported side effects of argatroban include heparin-induced thrombocytopenia, off label use, and international normalised ratio increased, based on 1,492 FDA adverse event reports from 2004 to 2025. 9.3% of reports found the drug to be ineffective.

#1 Reported: Heparin-induced ThrombocytopeniaAll side effects ↓Top Co-Medication: HeparinDrug interactions ↓56% of Reports Are AdultDemographics ↓

Argatroban side effects

Percentages show how often each reaction appears relative to total reports for argatroban.

1
Heparin-induced Thrombocytopenia9.8%146
2
Drug Ineffective9.3%139
3
Off Label Use6.4%96
4
International Normalised Ratio Increased5.8%87
5
Activated Partial Thromboplastin Time Prolonged4.5%67
6
Coagulation Time Prolonged3.8%56
7
Heparin-induced Thrombocytopenia3.2%48
8
Thrombocytopenia3.2%48
9
Deep Vein Thrombosis3.1%46
10
Haemorrhage3.0%45
11
Pulmonary Embolism2.9%44
12
Cerebral Infarction2.5%37
13
Thrombosis2.3%34
14
Disseminated Intravascular Coagulation2.3%34
15
Gastrointestinal Haemorrhage2.1%31

These are voluntary reports and do not establish that argatroban caused these reactions.

Report severity

87.6%Serious1,307 reports
42.5%Hospitalizations634 reports
20.9%Fatal312 reports

Seriousness is determined by the reporter, not by OpenClaim.

Argatroban drug interactions

Other drugs that appear in adverse event reports alongside argatroban. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Heparin20.9%312
2
Aspirin6.6%98
3
Warfarin6.3%94
4
Gemfibrozil3.5%52
5
Enoxaparin-sodium3.3%49
6
Fondaparinux-sodium2.5%38
7
Bivalirudin2.5%37
8
Alteplase2.4%36
9
Methylprednisolone2.3%34
10
Cilostazol2.0%30
11
Edaravone2.0%30
12
Dexamethasone1.9%28
13
Epinephrine1.8%27
14
Clopidogrel-bisulfate1.7%25
15
Azithromycin1.5%23

Taken alongside

1
Heparin13.9%207
2
Aspirin11.8%176
3
Warfarin9.2%138
4
Furosemide8.5%127
5
Acetaminophen7.7%115
6
Insulin7.1%106
7
Pantoprazole-sodium6.0%90
8
Metoprolol5.6%84
9
Vancomycin5.5%82
10
Epinephrine5.0%74
11
Prednisone4.6%68
12
Amiodarone-hydrochloride4.5%67
13
Methylprednisolone4.2%63
14
Ondansetron4.2%63
15
Propofol4.2%63

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports argatroban side effects

40.3% of argatroban adverse event reports involve female patients and 47.7% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.3%
Male47.7%
Unknown11.9%

Age group

< 21.2%
2–111.6%
12–170.3%
18–6456.3%
65+40.6%

What is argatroban used for

Conditions and purposes for which patients were taking argatroban when the adverse event was reported.

Activated Partial Thromboplastin Time AbnormalAcute Myeloid LeukaemiaAcute Myocardial InfarctionAngioplastyAnticoagulant TherapyAnticoagulation Drug Level Below TherapeuticAntiphospholipid SyndromeAntiplatelet TherapyAntithrombin Iii DecreasedAortic ThrombosisArterial Occlusive DiseaseArterial ThrombosisArteriosclerosis ObliteransAtrial FibrillationAtrial Thrombosis

Showing 15 of 157 indications

Argatroban brand names and reporting trend

Argatroban is sold under the brand name Argatroban.

Brand names

Argatroban1,978

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking argatroban with another medication?

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