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Aprotinin Side Effects

The most commonly reported side effects of aprotinin include pain, renal failure, and injury, based on 3,834 FDA adverse event reports from 2004 to 2025.

Aprotinin side effects

Percentages show how often each reaction appears relative to total reports for aprotinin.

1
Pain73.6%2,823
2
Renal Failure72.5%2,781
3
Injury70.2%2,693
4
Unevaluable Event66.6%2,555
5
Anxiety66.2%2,538
6
Fear61.1%2,341
7
Renal Injury53.1%2,035
8
Emotional Distress52.0%1,995
9
Anhedonia45.9%1,759
10
Renal Impairment44.0%1,687
11
Stress43.4%1,665
12
Death37.7%1,445
13
Multi-organ Failure34.5%1,322
14
Depression23.8%911
15
Cerebrovascular Accident14.6%561

These are voluntary reports and do not establish that aprotinin caused these reactions.

Report severity

98.9%Serious3,793 reports
30.1%Hospitalizations1,154 reports
50.4%Fatal1,933 reports

Seriousness is determined by the reporter, not by OpenClaim.

Aprotinin drug interactions

Other drugs that appear in adverse event reports alongside aprotinin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Heparin0.8%29
2
Protamine-sulfate0.5%20
3
Midazolam0.5%18
4
Vancomycin0.4%17
5
Propofol0.4%14
6
Mycophenolate0.3%12
7
Tacrolimus0.3%11
8
Aspirin0.3%11
9
Sufentanil-citrate0.3%10
10
Furosemide0.3%10
11
Methylprednisolone0.2%9
12
Cefuroxime0.2%8
13
Rocuronium-bromide0.2%8
14
Hydrocortisone0.2%8
15
Cefazolin-sodium0.2%8

Taken alongside

1
Heparin50.2%1,926
2
Furosemide32.8%1,258
3
Protamine-sulfate28.9%1,107
4
Midazolam27.4%1,049
5
Nitroglycerin23.6%904
6
Metoprolol23.6%904
7
Fentanyl21.0%805
8
Insulin20.7%794
9
Cefazolin-sodium20.0%767
10
Vancomycin16.8%643
11
Mannitol15.5%596
12
Lisinopril14.3%548
13
Potassium-chloride13.6%522
14
Dopamine-hydrochloride13.4%515
15
Epinephrine13.0%500

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports aprotinin side effects

36.9% of aprotinin adverse event reports involve female patients and 58.0% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.9%
Male58.0%
Unknown5.1%

Age group

< 21.4%
2–110.8%
12–170.5%
18–6447.4%
65+49.9%

What is aprotinin used for

Conditions and purposes for which patients were taking aprotinin when the adverse event was reported.

Abdominal AdhesionsAbdominal Hernia RepairAbscessAbscess DrainageAcneAdhesiolysisAnastomotic StenosisAneurysm RepairAneurysmectomyAngina PectorisAngioplastyAnomalous Pulmonary Venous ConnectionAnticoagulant TherapyAorta SubstitutionAortic Anastomosis

Showing 15 of 244 indications

Aprotinin brand names and reporting trend

Aprotinin is sold under the brand name Trasylol.

Brand names

Trasylol343

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking aprotinin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.