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Aprepitant Side Effects

The most commonly reported side effects of aprepitant include nausea, fatigue, and pyrexia, based on 20,699 FDA adverse event reports from 2004 to 2025.

Aprepitant side effects

Percentages show how often each reaction appears relative to total reports for aprepitant.

1
Nausea10.6%2,204
2
Fatigue8.7%1,796
3
Pyrexia8.1%1,685
4
Dyspnoea8.1%1,675
5
Diarrhoea7.6%1,571
6
Off Label Use7.1%1,464
7
Vomiting7.0%1,441
8
Alopecia6.8%1,404
9
Rash5.9%1,230
10
Hypersensitivity5.8%1,206
11
Febrile Neutropenia5.5%1,145
12
Infusion Related Reaction5.3%1,106
13
Decreased Appetite5.2%1,074
14
Pruritus5.2%1,070
15
Stomatitis5.0%1,030

These are voluntary reports and do not establish that aprepitant caused these reactions.

Report severity

88.2%Serious18,258 reports
53.5%Hospitalizations11,065 reports
16.2%Fatal3,356 reports

Seriousness is determined by the reporter, not by OpenClaim.

Aprepitant drug interactions

Other drugs that appear in adverse event reports alongside aprepitant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Fosaprepitant-dimeglumine28.3%5,855
2
Carboplatin11.8%2,444
3
Cisplatin10.3%2,141
4
Fluorouracil8.8%1,830
5
Prednisone8.8%1,822
6
Ondansetron8.5%1,758
7
Paclitaxel8.4%1,738
8
Cyclophosphamide8.3%1,717
9
Rituximab8.2%1,689
10
Oxaliplatin7.6%1,565
11
Methotrexate7.3%1,501
12
Docetaxel7.1%1,465
13
Acetaminophen7.0%1,458
14
Doxorubicin-hydrochloride7.0%1,454
15
Bevacizumab6.6%1,360

Taken alongside

1
Dexamethasone37.1%7,685
2
Fosaprepitant-dimeglumine32.4%6,716
3
Ondansetron26.4%5,456
4
Acetaminophen17.8%3,675
5
Palonosetron-hydrochloride16.9%3,499
6
Pantoprazole-sodium10.8%2,243
7
Lorazepam9.7%2,004
8
Metoclopramide-hydrochloride8.9%1,843
9
Diphenhydramine8.4%1,730
10
Granisetron8.3%1,717
11
Pegfilgrastim7.4%1,539
12
Furosemide6.9%1,428
13
Omeprazole6.4%1,327
14
Methylprednisolone6.4%1,317
15
Oxycodone6.2%1,274

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports aprepitant side effects

56.1% of aprepitant adverse event reports involve female patients and 34.4% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.1%
Male34.4%
Unknown9.4%

Age group

< 20.5%
2–111.9%
12–172.4%
18–6462.2%
65+33.1%

What is aprepitant used for

Conditions and purposes for which patients were taking aprepitant when the adverse event was reported.

Abdominal DiscomfortAbdominal MigraineAbdominal PainAcute Coronary SyndromeAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma Of The CervixAdenocarcinoma PancreasAdjuvant TherapyAdverse Drug ReactionAdverse Event

Showing 15 of 334 indications

Aprepitant brand names and reporting trend

Aprepitant is sold under the brand name Cinvanti.

Brand names

Cinvanti12,670

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking aprepitant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.