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Apraclonidine Side Effects

The most commonly reported side effects of apraclonidine include dizziness, nausea, and anaemia, based on 581 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Apraclonidine side effects

Percentages show how often each reaction appears relative to total reports for apraclonidine.

1
Dizziness8.8%51
2
Nausea7.9%46
3
Anaemia7.4%43
4
Fatigue7.1%41
5
Dyspnoea6.9%40
6
Diarrhoea5.5%32
7
Hypertension4.8%28
8
Headache4.8%28
9
Constipation4.6%27
10
Drug Interaction4.5%26
11
Drug Ineffective4.3%25
12
Rectal Haemorrhage4.3%25
13
General Physical Health Deterioration4.3%25
14
Fall4.1%24
15
Back Pain4.0%23

These are voluntary reports and do not establish that apraclonidine caused these reactions.

Report severity

88.5%Serious514 reports
53.4%Hospitalizations310 reports
8.4%Fatal49 reports

Seriousness is determined by the reporter, not by OpenClaim.

Apraclonidine drug interactions

Other drugs that appear in adverse event reports alongside apraclonidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Timolol6.9%40
2
Gemfibrozil4.6%27
3
Acetazolamide3.8%22
4
Dorzolamide-hydrochloride3.4%20
5
Aspirin3.4%20
6
Dexamethasone3.3%19
7
Pilocarpine3.3%19
8
Latanoprost3.3%19
9
Anastrozole3.1%18
10
Docetaxel3.1%18
11
Pertuzumab3.1%18
12
Trastuzumab3.1%18
13
Bevacizumab2.9%17
14
Tacrolimus2.8%16
15
Furosemide2.6%15

Taken alongside

1
Furosemide13.9%81
2
Pantoprazole-sodium12.4%72
3
Metoprolol11.5%67
4
Timolol11.4%66
5
Ramipril11.4%66
6
Bisoprolol-fumarate10.5%61
7
Amlodipine10.2%59
8
Aspirin10.2%59
9
Atorvastatin-calcium10.2%59
10
Acetaminophen9.5%55
11
Insulin8.4%49
12
Phentermine8.4%49
13
Prednisolone8.3%48
14
Dexamethasone7.2%42
15
Dorzolamide-hydrochloride6.9%40

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports apraclonidine side effects

50.9% of apraclonidine adverse event reports involve female patients and 42.3% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.9%
Male42.3%
Unknown6.7%

Age group

< 23.4%
2–114.5%
12–170.6%
18–6435.0%
65+56.5%

What is apraclonidine used for

Conditions and purposes for which patients were taking apraclonidine when the adverse event was reported.

Alcohol Withdrawal SyndromeAngle Closure GlaucomaBipolar I DisorderBlood PressureBlood Pressure AbnormalBlood Pressure MeasurementCardiac DisorderCataract OperationDeliriumDisturbance In AttentionDrug Use For Unknown IndicationDrug Withdrawal SyndromeDrug Withdrawal Syndrome NeonatalEye DisorderEye Inflammation

Showing 15 of 55 indications

Apraclonidine brand names and reporting trend

Apraclonidine is sold under the brand name Apraclonidine Hydrochloride.

Brand names

Apraclonidine Hydrochloride332

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking apraclonidine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.