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Apomorphine Side Effects

The most commonly reported side effects of apomorphine include nausea, pain, and fatigue, based on 85,758 FDA adverse event reports from 2004 to 2025. 5.9% of reports found the drug to be ineffective.

Apomorphine side effects

Percentages show how often each reaction appears relative to total reports for apomorphine.

1
Nausea8.1%6,904
2
Pain6.1%5,256
3
Drug Ineffective5.9%5,071
4
Fatigue5.1%4,356
5
Vomiting5.1%4,331
6
Death4.8%4,079
7
Off Label Use4.7%4,035
8
Toxicity To Various Agents4.7%3,998
9
Diarrhoea3.9%3,337
10
Dizziness3.8%3,242
11
Somnolence3.7%3,210
12
Dyspnoea3.7%3,179
13
Headache3.6%3,116
14
Malaise3.2%2,752
15
Pneumonia3.1%2,685

These are voluntary reports and do not establish that apomorphine caused these reactions.

Report severity

81.5%Serious69,929 reports
38.7%Hospitalizations33,188 reports
25.4%Fatal21,812 reports

Seriousness is determined by the reporter, not by OpenClaim.

Apomorphine drug interactions

Other drugs that appear in adverse event reports alongside apomorphine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen7.4%6,316
2
Fentanyl5.9%5,043
3
Oxycodone5.8%4,944
4
Tramadol-hydrochloride3.5%3,017
5
Dihydrocodeine-bitartrate3.5%2,959
6
Diazepam3.4%2,942
7
Pregabalin3.4%2,895
8
Hydromorphone-hydrochloride3.2%2,739
9
Adalimumab3.0%2,563
10
Gabapentin2.9%2,529
11
Methadone-hydrochloride2.8%2,415
12
Lenalidomide2.8%2,403
13
Methotrexate2.6%2,252
14
Rituximab2.6%2,196
15
Alprazolam2.4%2,098

Taken alongside

1
Acetaminophen19.6%16,790
2
Ondansetron10.6%9,074
3
Oxycodone9.6%8,256
4
Furosemide8.9%7,590
5
Omeprazole8.2%7,052
6
Aspirin8.1%6,936
7
Gabapentin7.8%6,718
8
Pantoprazole-sodium7.6%6,490
9
Lorazepam7.3%6,277
10
Dexamethasone6.8%5,797
11
Albuterol6.7%5,713
12
Levothyroxine-sodium6.4%5,476
13
Prednisone6.0%5,170
14
Ergocalciferol5.6%4,810
15
Fentanyl5.5%4,734

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports apomorphine side effects

48.2% of apomorphine adverse event reports involve female patients and 44.1% involve male patients. The largest age group is adult at 59%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.2%
Male44.1%
Unknown7.7%

Age group

< 21.8%
2–112.1%
12–172.1%
18–6459.0%
65+35.0%

What is apomorphine used for

Conditions and purposes for which patients were taking apomorphine when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal HerniaAbdominal OperationAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal RigidityAbdominal SepsisAbdominal TendernessAbscess DrainageAbscess IntestinalAcarodermatitisAccidental Drug Intake By ChildAccidental Exposure

Showing 15 of 1,417 indications

Apomorphine brand names and reporting trend

Apomorphine is sold under the brand name Apokyn.

Brand names

Apokyn87,259

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking apomorphine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.