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Apixaban Side Effects

The most commonly reported side effects of apixaban include death, dyspnoea, and fatigue, based on 264,300 FDA adverse event reports from 2007 to 2025. 2.0% of reports found the drug to be ineffective.

Apixaban side effects

Percentages show how often each reaction appears relative to total reports for apixaban.

1
Death9.2%24,333
2
Dyspnoea4.6%12,089
3
Fatigue4.3%11,407
4
Off Label Use4.3%11,352
5
Atrial Fibrillation3.9%10,363
6
Diarrhoea3.5%9,336
7
Fall3.5%9,170
8
Cerebrovascular Accident3.3%8,774
9
Dizziness3.1%8,284
10
Nausea3.0%8,040
11
Headache2.8%7,319
12
Thrombosis2.7%7,230
13
Cardiac Disorder2.3%6,102
14
Asthenia2.3%6,066
15
Pneumonia2.3%6,010

These are voluntary reports and do not establish that apixaban caused these reactions.

Report severity

75.4%Serious199,179 reports
33.0%Hospitalizations87,222 reports
14.9%Fatal39,298 reports

Seriousness is determined by the reporter, not by OpenClaim.

Apixaban drug interactions

Other drugs that appear in adverse event reports alongside apixaban. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide3.9%10,225
2
Treprostinil2.8%7,425
3
Aspirin1.8%4,697
4
Furosemide1.5%4,028
5
Bisoprolol-fumarate1.4%3,664
6
Amiodarone-hydrochloride1.2%3,280
7
Pomalidomide1.2%3,242
8
Valsartan1.0%2,717
9
Metoprolol1.0%2,671
10
Atorvastatin-calcium1.0%2,630
11
Metformin0.9%2,455
12
Pantoprazole-sodium0.9%2,437
13
Prednisone0.9%2,430
14
Omeprazole0.9%2,302
15
Sacubitril0.8%2,170

Taken alongside

1
Metoprolol10.5%27,819
2
Furosemide10.2%27,087
3
Atorvastatin-calcium9.8%25,845
4
Acetaminophen7.7%20,400
5
Levothyroxine-sodium7.6%20,030
6
Ergocalciferol7.2%18,919
7
Omeprazole6.2%16,391
8
Aspirin6.2%16,287
9
Amlodipine6.1%16,199
10
Pantoprazole-sodium6.1%16,121
11
Albuterol4.9%12,900
12
Gabapentin4.7%12,378
13
Metformin4.4%11,595
14
Bisoprolol-fumarate4.4%11,499
15
Lisinopril4.0%10,508

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports apixaban side effects

47.5% of apixaban adverse event reports involve female patients and 43.9% involve male patients. The largest age group is elderly at 78%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.5%
Male43.9%
Unknown8.6%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6421.4%
65+78.4%

What is apixaban used for

Conditions and purposes for which patients were taking apixaban when the adverse event was reported.

Abdominal DiscomfortAbnormal Clotting FactorAccidental Exposure To Product By ChildAcetabulum FractureAcquired DysfibrinogenaemiaActinic KeratosisAcute Coronary SyndromeAcute Left Ventricular FailureAcute Myocardial InfarctionAdverse EventAmaurosis FugaxAmyloidosisAmyloidosis SenileAnaemiaAnaesthesia

Showing 15 of 1,341 indications

Apixaban brand names and reporting trend

Apixaban is sold under the brand name Eliquis.

Brand names

Eliquis70,362

Quarterly reports (20072025)

20072010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking apixaban with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.