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Anagrelide Side Effects

The most commonly reported side effects of anagrelide include off label use, fatigue, and platelet count increased, based on 2,667 FDA adverse event reports from 2004 to 2025. 3.1% of reports found the drug to be ineffective.

Anagrelide side effects

Percentages show how often each reaction appears relative to total reports for anagrelide.

1
Off Label Use8.0%213
2
Fatigue5.8%155
3
Platelet Count Increased5.3%141
4
Headache4.6%124
5
Anaemia4.5%119
6
Diarrhoea3.9%103
7
Dizziness3.7%98
8
Haemoglobin Decreased3.7%98
9
Dyspnoea3.5%93
10
Death3.4%91
11
Drug Ineffective3.1%83
12
Nausea2.8%75
13
Asthenia2.7%73
14
Fall2.3%61
15
Platelet Count Decreased2.1%57

These are voluntary reports and do not establish that anagrelide caused these reactions.

Report severity

76.2%Serious2,033 reports
34.8%Hospitalizations928 reports
11.5%Fatal307 reports

Seriousness is determined by the reporter, not by OpenClaim.

Anagrelide drug interactions

Other drugs that appear in adverse event reports alongside anagrelide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ruxolitinib25.1%670
2
Hydroxyurea9.2%246
3
Aspirin4.0%107
4
Lenalidomide2.4%64
5
Apixaban1.8%48
6
Imatinib-mesylate1.6%44
7
Ropeginterferon-alfa-2b-njft1.4%38
8
Peginterferon1.3%36
9
Nilotinib1.2%33
10
Dasatinib1.1%29
11
Furosemide1.1%29
12
Amlodipine0.9%25
13
Deferasirox0.9%25
14
Epoetin0.9%23
15
Pantoprazole-sodium0.9%23

Taken alongside

1
Aspirin25.7%685
2
Hydroxyurea17.2%459
3
Furosemide9.9%264
4
Metoprolol9.6%255
5
Amlodipine9.4%250
6
Levothyroxine-sodium8.5%228
7
Atorvastatin-calcium7.6%204
8
Acetaminophen7.6%203
9
Ergocalciferol7.3%196
10
Omeprazole6.8%181
11
Allopurinol6.6%177
12
Lisinopril5.8%154
13
Hydrochlorothiazide5.5%146
14
Folic-acid5.2%139
15
Pantoprazole-sodium4.5%121

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports anagrelide side effects

44.1% of anagrelide adverse event reports involve female patients and 30.7% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.1%
Male30.7%
Unknown25.1%

Age group

< 20.2%
2–110.4%
12–170.0%
18–6436.7%
65+62.7%

What is anagrelide used for

Conditions and purposes for which patients were taking anagrelide when the adverse event was reported.

Accidental Exposure To Product By ChildAcute Myeloid LeukaemiaAnaemiaAnticoagulant TherapyAntiplatelet TherapyAntiplatelet TherapyAtrial FibrillationBlood Count AbnormalBlood DisorderBlood Pressure MeasurementBone Marrow DisorderBlood DisorderBreast Cancer FemaleCalr Gene MutationCardiac Failure

Showing 15 of 81 indications

Anagrelide brand names and reporting trend

Anagrelide is sold under the brand name Agrylin.

Brand names

Agrylin20

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking anagrelide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.