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Amprenavir Side Effects

The most commonly reported side effects of amprenavir include viral mutation identified, virologic failure, and pathogen resistance, based on 1,070 FDA adverse event reports from 2004 to 2025. 2.4% of reports found the drug to be ineffective.

Amprenavir side effects

Percentages show how often each reaction appears relative to total reports for amprenavir.

1
Viral Mutation Identified7.6%81
2
Virologic Failure7.6%81
3
Pathogen Resistance5.7%61
4
Pyrexia5.1%55
5
Drug Interaction5.1%55
6
Drug Resistance5.1%55
7
Treatment Failure5.1%55
8
Drug Interaction3.6%39
9
Diarrhoea3.3%35
10
Nausea2.8%30
11
Rash2.8%30
12
Immune Reconstitution Syndrome2.8%30
13
Foetal Exposure During Pregnancy2.8%30
14
Abdominal Pain2.7%29
15
Drug Exposure During Pregnancy2.5%27

These are voluntary reports and do not establish that amprenavir caused these reactions.

Report severity

94.5%Serious1,011 reports
34.7%Hospitalizations371 reports
10.1%Fatal108 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amprenavir drug interactions

Other drugs that appear in adverse event reports alongside amprenavir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ritonavir57.3%613
2
Lamivudine41.9%448
3
Tenofovir39.6%424
4
Zidovudine27.9%298
5
Abacavir27.3%292
6
Didanosine23.2%248
7
Emtricitabine22.3%239
8
Lopinavir21.3%228
9
Stavudine21.3%228
10
Efavirenz20.4%218
11
Nevirapine19.6%210
12
Nelfinavir-mesylate15.4%165
13
Saquinavir14.9%159
14
Atazanavir-sulfate14.4%154
15
Darunavir14.3%153

Taken alongside

1
Ritonavir21.2%227
2
Lamivudine15.8%169
3
Tenofovir14.1%151
4
Abacavir9.7%104
5
Zidovudine7.9%84
6
Sulfamethoxazole7.7%82
7
Didanosine7.2%77
8
Lopinavir7.1%76
9
Trimethoprim6.7%72
10
Emtricitabine6.7%72
11
Stavudine5.0%53
12
Efavirenz4.9%52
13
Enfuvirtide4.7%50
14
Saquinavir4.2%45
15
Nevirapine4.2%45

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amprenavir side effects

23.6% of amprenavir adverse event reports involve female patients and 59.7% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female23.6%
Male59.7%
Unknown16.6%

Age group

< 22.9%
2–112.1%
12–173.3%
18–6485.9%
65+5.8%

What is amprenavir used for

Conditions and purposes for which patients were taking amprenavir when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hiv InfectionAntiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAntiretroviral TherapyChronic Hepatitis CDrug Exposure During PregnancyDrug Use For Unknown IndicationHepatitis BHepatitis CHepatitis ViralHiv InfectionHiv Infection Cdc Category B3Hiv Infection Cdc Category C

Showing 15 of 33 indications

Amprenavir brand names and reporting trend

Amprenavir is sold under the brand name Agenerase.

Brand names

Agenerase1,094

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amprenavir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.