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Amphotericin Side Effects

The most commonly reported side effects of amphotericin include off label use, pyrexia, and condition aggravated, based on 23,882 FDA adverse event reports from 2004 to 2025. 21.1% of reports found the drug to be ineffective.

Amphotericin side effects

Percentages show how often each reaction appears relative to total reports for amphotericin.

1
Drug Ineffective21.1%5,036
2
Off Label Use10.1%2,424
3
Pyrexia4.1%979
4
Condition Aggravated3.7%887
5
Acute Kidney Injury3.7%872
6
Multiple Organ Dysfunction Syndrome3.0%711
7
Febrile Neutropenia2.7%649
8
Product Use In Unapproved Indication2.6%623
9
Death2.4%577
10
Sepsis2.4%577
11
Pneumonia2.3%556
12
Neutropenia2.2%536
13
Septic Shock2.2%534
14
Hypokalaemia2.2%533
15
Renal Impairment2.1%512

These are voluntary reports and do not establish that amphotericin caused these reactions.

Report severity

95.6%Serious22,834 reports
43.7%Hospitalizations10,441 reports
36.6%Fatal8,736 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amphotericin drug interactions

Other drugs that appear in adverse event reports alongside amphotericin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Voriconazole12.6%3,006
2
Tacrolimus7.5%1,797
3
Fluconazole6.7%1,608
4
Vancomycin6.3%1,512
5
Mycophenolate6.1%1,453
6
Prednisone6.0%1,423
7
Cytarabine5.7%1,366
8
Posaconazole5.5%1,302
9
Dexamethasone5.3%1,263
10
Meropenem5.2%1,235
11
Cyclophosphamide5.0%1,200
12
Caspofungin-acetate5.0%1,197
13
Methotrexate4.8%1,137
14
Prednisolone4.6%1,091
15
Methylprednisolone4.5%1,074

Taken alongside

1
Vancomycin10.6%2,533
2
Meropenem9.6%2,292
3
Acyclovir8.1%1,943
4
Voriconazole8.0%1,921
5
Acetaminophen8.0%1,920
6
Sulfamethoxazole7.6%1,825
7
Fluconazole7.2%1,718
8
Furosemide6.7%1,597
9
Trimethoprim6.5%1,547
10
Methylprednisolone6.1%1,448
11
Prednisone6.0%1,427
12
Pantoprazole-sodium5.8%1,397
13
Ondansetron5.0%1,200
14
Dexamethasone4.9%1,167
15
Caspofungin-acetate4.5%1,066

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amphotericin side effects

37.5% of amphotericin adverse event reports involve female patients and 53.4% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.5%
Male53.4%
Unknown9.1%

Age group

< 23.7%
2–119.4%
12–176.1%
18–6455.7%
65+25.1%

What is amphotericin used for

Conditions and purposes for which patients were taking amphotericin when the adverse event was reported.

Abdominal AbscessAbdominal InfectionAbdominal SepsisAbscessAbscess FungalAbscess LimbAcanthamoeba InfectionAcanthamoeba KeratitisAcinetobacter BacteraemiaAcinetobacter InfectionAcute Kidney InjuryAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid Leukaemia

Showing 15 of 1,144 indications

Amphotericin brand names and reporting trend

Amphotericin is sold under the brand name Ambisome.

Brand names

Ambisome19,321

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amphotericin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.