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Amphetamine Side Effects

The most commonly reported side effects of amphetamine include drug abuse, toxicity to various agents, and fatigue, based on 64,438 FDA adverse event reports from 2004 to 2025. 8.5% of reports found the drug to be ineffective.

Amphetamine side effects

Percentages show how often each reaction appears relative to total reports for amphetamine.

1
Drug Abuse9.2%5,925
2
Drug Ineffective8.5%5,469
3
Toxicity To Various Agents5.7%3,664
4
Fatigue5.6%3,579
5
Nausea5.0%3,239
6
Headache4.7%3,020
7
Anxiety4.3%2,786
8
Depression3.6%2,351
9
Feeling Abnormal3.4%2,197
10
Somnolence3.2%2,037
11
Pain3.1%1,971
12
Dizziness3.1%1,967
13
Insomnia2.9%1,851
14
Off Label Use2.8%1,778
15
Vomiting2.3%1,495

These are voluntary reports and do not establish that amphetamine caused these reactions.

Report severity

57.0%Serious36,726 reports
14.8%Hospitalizations9,514 reports
16.7%Fatal10,790 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amphetamine drug interactions

Other drugs that appear in adverse event reports alongside amphetamine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate21.6%13,949
2
Dextroamphetamine16.5%10,648
3
Fentanyl6.8%4,386
4
Oxycodone3.5%2,239
5
Cocaine-hydrochloride3.1%1,999
6
Alprazolam3.0%1,921
7
Acetaminophen2.6%1,660
8
Lisdexamfetamine-dimesylate2.3%1,482
9
Diazepam2.1%1,360
10
Bupropion2.1%1,332
11
Buprenorphine1.9%1,247
12
Methadone-hydrochloride1.9%1,222
13
Magnesium-oxybate1.9%1,197
14
Alcohol1.8%1,190
15
Methylphenidate1.8%1,150

Taken alongside

1
Dextroamphetamine55.5%35,783
2
Ergocalciferol11.6%7,460
3
Acetaminophen11.2%7,224
4
Gabapentin7.9%5,070
5
Bupropion7.6%4,873
6
Albuterol7.3%4,721
7
Levothyroxine-sodium7.2%4,610
8
Clonazepam6.9%4,478
9
Ibuprofen6.9%4,476
10
Alprazolam6.6%4,251
11
Omeprazole6.3%4,083
12
Fluticasone6.1%3,935
13
Duloxetine-hydrochloride5.8%3,766
14
Oxycodone5.0%3,241
15
Fluoxetine-hydrochloride5.0%3,210

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amphetamine side effects

56.7% of amphetamine adverse event reports involve female patients and 35.0% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.7%
Male35.0%
Unknown8.2%

Age group

< 20.6%
2–113.7%
12–174.7%
18–6486.2%
65+4.8%

What is amphetamine used for

Conditions and purposes for which patients were taking amphetamine when the adverse event was reported.

Abnormal BehaviourAccidental Drug Intake By ChildAccidental ExposureAccidental Exposure To Product By ChildAccidental OverdoseAcquired Immunodeficiency SyndromeAddAdhdAdverse EventAdverse ReactionAffect LabilityAffective DisorderAggressionAgitationAmnesia

Showing 15 of 493 indications

Amphetamine brand names and reporting trend

Amphetamine is sold under several brand names including Adzenys Xr-odt, Dextroamp Saccharate,amp Aspartate,dextroamp Sulfate And Amp Sulfate, Dyanavel Xr.

Brand names

Adzenys Xr-odt19,178
Dextroamp Saccharate,amp Aspartate,dextroamp Sulfate And Amp Sulfate1,931
Dyanavel Xr193
Dextroamphetamine Saccharate; Amphetamine Aspartate Monohydrate; Dextroamphetamine Sulfate; Amphetamine Sulfate97
Delcobese43
Biphetamine 204

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amphetamine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.