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Amoxicillin Side Effects

The most commonly reported side effects of amoxicillin include diarrhoea, acute kidney injury, and drug hypersensitivity, based on 136,115 FDA adverse event reports from 2004 to 2025. 4.1% of reports found the drug to be ineffective.

Amoxicillin side effects

Percentages show how often each reaction appears relative to total reports for amoxicillin.

1
Diarrhoea4.7%6,428
2
Acute Kidney Injury4.5%6,154
3
Drug Hypersensitivity4.2%5,738
4
Drug Ineffective4.1%5,577
5
Nausea3.9%5,354
6
Dyspnoea3.9%5,319
7
Chronic Kidney Disease3.9%5,317
8
Off Label Use3.9%5,266
9
Pyrexia3.6%4,930
10
Rash3.5%4,796
11
Fatigue3.5%4,752
12
Vomiting3.2%4,367
13
Pain3.1%4,239
14
Headache2.9%3,993
15
Pruritus2.8%3,862

These are voluntary reports and do not establish that amoxicillin caused these reactions.

Report severity

83.2%Serious113,233 reports
43.0%Hospitalizations58,535 reports
9.1%Fatal12,440 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amoxicillin drug interactions

Other drugs that appear in adverse event reports alongside amoxicillin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Clavulanate-potassium11.4%15,489
2
Omeprazole5.3%7,177
3
Pantoprazole-sodium4.2%5,784
4
Esomeprazole4.1%5,515
5
Lenalidomide3.9%5,286
6
Clarithromycin3.8%5,194
7
Acetaminophen3.8%5,116
8
Lansoprazole3.6%4,955
9
Prednisone3.1%4,212
10
Dexamethasone3.0%4,034
11
Metronidazole2.7%3,729
12
Ibuprofen2.3%3,125
13
Ciprofloxacin2.3%3,099
14
Rituximab2.1%2,861
15
Azithromycin2.0%2,774

Taken alongside

1
Acetaminophen16.9%22,968
2
Clavulanate-potassium13.1%17,857
3
Aspirin9.9%13,440
4
Albuterol9.3%12,598
5
Omeprazole9.1%12,435
6
Furosemide8.5%11,545
7
Prednisone7.7%10,535
8
Atorvastatin-calcium7.1%9,683
9
Levothyroxine-sodium6.9%9,418
10
Ergocalciferol6.9%9,401
11
Ibuprofen6.7%9,083
12
Amlodipine6.5%8,884
13
Ondansetron6.0%8,231
14
Acyclovir5.9%8,012
15
Fluticasone5.8%7,897

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amoxicillin side effects

51.9% of amoxicillin adverse event reports involve female patients and 39.3% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.9%
Male39.3%
Unknown8.8%

Age group

< 22.7%
2–115.0%
12–172.9%
18–6452.9%
65+36.5%

What is amoxicillin used for

Conditions and purposes for which patients were taking amoxicillin when the adverse event was reported.

Abdominal AbscessAbdominal DiscomfortAbdominal DistensionAbdominal InfectionAbdominal OperationAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal SepsisAbdominal Wall HaematomaAbnormal BehaviourAbortion SpontaneousAbortion ThreatenedAbscessAbscess Drainage

Showing 15 of 2,788 indications

Amoxicillin brand names and reporting trend

Amoxicillin is sold under the brand name Augmentin '125'.

Brand names

Augmentin '125'97,449

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amoxicillin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.