OpenClaim

Amoxapine Side Effects

The most commonly reported side effects of amoxapine include poisoning, drug abuse, and completed suicide, based on 497 FDA adverse event reports from 2004 to 2025. 3.4% of reports found the drug to be ineffective.

Amoxapine side effects

Percentages show how often each reaction appears relative to total reports for amoxapine.

1
Poisoning7.4%37
2
Drug Abuse7.2%36
3
Completed Suicide4.4%22
4
Toxicity To Various Agents4.2%21
5
Pyrexia3.6%18
6
Asphyxia3.6%18
7
Drug Ineffective3.4%17
8
Drug Ineffective3.0%15
9
Somnolence3.0%15
10
Depression2.8%14
11
Drug Interaction2.6%13
12
Overdose2.6%13
13
Convulsion2.6%13
14
Depression2.6%13
15
Hepatic Function Abnormal2.4%12

These are voluntary reports and do not establish that amoxapine caused these reactions.

Report severity

83.3%Serious414 reports
37.6%Hospitalizations187 reports
23.7%Fatal118 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amoxapine drug interactions

Other drugs that appear in adverse event reports alongside amoxapine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paroxetine10.1%50
2
Loxapine10.1%50
3
Diazepam7.6%38
4
Oxazepam7.6%38
5
Sertraline-hydrochloride7.4%37
6
Acetaminophen6.8%34
7
Zolpidem-tartrate6.6%33
8
Quetiapine-fumarate6.0%30
9
Mirtazapine6.0%30
10
Duloxetine-hydrochloride4.8%24
11
Dihydrocodeine-bitartrate4.6%23
12
Cocaine-hydrochloride4.4%22
13
Alprazolam4.2%21
14
Olanzapine4.0%20
15
Clomipramine-hydrochloride3.8%19

Taken alongside

1
Paroxetine8.0%40
2
Aspirin7.4%37
3
Acetaminophen6.8%34
4
Lorazepam6.4%32
5
Sertraline-hydrochloride6.0%30
6
Levothyroxine-sodium5.4%27
7
Trazodone-hydrochloride5.0%25
8
Fluvoxamine-maleate5.0%25
9
Gabapentin4.8%24
10
Metoprolol4.6%23
11
Hydrochlorothiazide4.6%23
12
Furosemide4.6%23
13
Amlodipine4.6%23
14
Diazepam4.4%22
15
Alprazolam4.0%20

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amoxapine side effects

57.7% of amoxapine adverse event reports involve female patients and 36.0% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.7%
Male36.0%
Unknown6.2%

Age group

< 20.3%
2–110.0%
12–171.0%
18–6474.7%
65+24.0%

What is amoxapine used for

Conditions and purposes for which patients were taking amoxapine when the adverse event was reported.

Analgesic TherapyAntidepressant TherapyAnxietyAttention Deficit Hyperactivity DisorderAutonomic Nervous System ImbalanceBipolar DisorderBipolar I DisorderBlood Pressure AbnormalBlood Pressure MeasurementDepressed MoodDepressionDepressive DelusionDrug Use For Unknown IndicationDepressionDepressive Symptom

Showing 15 of 39 indications

Amoxapine brand names and reporting trend

Amoxapine is sold under the brand name Amoxapine.

Brand names

Amoxapine524

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amoxapine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.