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Amivantamab Side Effects

The most commonly reported side effects of amivantamab include infusion related reaction, rash, and off label use, based on 3,566 FDA adverse event reports from 2004 to 2025.

Amivantamab side effects

Percentages show how often each reaction appears relative to total reports for amivantamab.

1
Infusion Related Reaction19.1%681
2
Rash12.7%453
3
Off Label Use5.6%198
4
Dyspnoea3.8%137
5
Paronychia3.6%128
6
Nausea3.1%109
7
Pulmonary Embolism2.6%91
8
Death2.4%87
9
Dermatitis Acneiform2.4%86
10
Fatigue2.3%83
11
Thrombocytopenia2.3%83
12
Non-small Cell Lung Cancer2.3%82
13
Oxygen Saturation Decreased2.3%81
14
Diarrhoea2.2%80
15
Neutropenia2.2%80

These are voluntary reports and do not establish that amivantamab caused these reactions.

Report severity

71.8%Serious2,560 reports
30.1%Hospitalizations1,072 reports
9.9%Fatal352 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amivantamab drug interactions

Other drugs that appear in adverse event reports alongside amivantamab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pemetrexed19.7%704
2
Carboplatin18.0%641
3
Lazertinib-mesylate8.3%297
4
Osimertinib-mesylate3.0%107
5
Apixaban0.8%30
6
Doxycycline0.5%19
7
Lansoprazole0.5%18
8
Bevacizumab0.4%16
9
Levofloxacin0.4%15
10
Acetaminophen0.4%13
11
Dexamethasone0.4%13
12
Prednisolone0.3%11
13
Azithromycin0.3%11
14
Pembrolizumab0.3%11
15
Rivaroxaban0.3%10

Taken alongside

1
Carboplatin7.0%249
2
Pemetrexed6.7%239
3
Acetaminophen6.6%234
4
Dexamethasone5.6%198
5
Doxycycline4.2%149
6
Folic-acid4.0%143
7
Ondansetron3.8%134
8
Furosemide2.9%103
9
Apixaban2.8%99
10
Methylprednisolone2.7%98
11
Omeprazole2.6%92
12
Pantoprazole-sodium2.5%89
13
Atorvastatin-calcium2.4%85
14
Prednisone2.4%84
15
Osimertinib-mesylate2.3%83

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amivantamab side effects

42.8% of amivantamab adverse event reports involve female patients and 27.1% involve male patients. The largest age group is elderly at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.8%
Male27.1%
Unknown30.1%

Age group

< 20.2%
2–110.3%
12–170.1%
18–6444.7%
65+54.8%

What is amivantamab used for

Conditions and purposes for which patients were taking amivantamab when the adverse event was reported.

Abdominal Pain UpperAntiinflammatory TherapyAsthmaAdenocarcinomaAdenocarcinoma MetastaticAdenosquamous Cell Lung CancerAsthmaBacterial InfectionBlood DisorderBronchitisBronchitis ChronicBronchopneumoniaBladder CancerBronchial CarcinomaBronchospasm

Showing 15 of 86 indications

Amivantamab brand names and reporting trend

Amivantamab is sold under brand names including Rybrevant Faspro, Rybrevant.

Brand names

Rybrevant Faspro1,341
Rybrevant4

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amivantamab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.