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Aminophylline Side Effects

The most commonly reported side effects of aminophylline include dyspnoea, asthma, and vomiting, based on 2,492 FDA adverse event reports from 2004 to 2025. 6.4% of reports found the drug to be ineffective.

Aminophylline side effects

Percentages show how often each reaction appears relative to total reports for aminophylline.

1
Dyspnoea16.5%410
2
Asthma13.8%343
3
Vomiting13.0%325
4
Pneumonia12.9%322
5
Wheezing11.3%281
6
Drug Hypersensitivity11.0%274
7
Oedema10.5%262
8
Malaise7.7%193
9
Off Label Use7.5%186
10
Pain7.4%184
11
Cough6.5%163
12
Drug Ineffective6.4%159
13
Overdose5.8%144
14
Lower Respiratory Tract Infection5.3%133
15
Chest Pain5.0%125

These are voluntary reports and do not establish that aminophylline caused these reactions.

Report severity

95.7%Serious2,385 reports
46.6%Hospitalizations1,162 reports
15.7%Fatal390 reports

Seriousness is determined by the reporter, not by OpenClaim.

Aminophylline drug interactions

Other drugs that appear in adverse event reports alongside aminophylline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ciprofloxacin15.8%393
2
Albuterol15.0%374
3
Rosuvastatin13.6%338
4
Amlodipine13.1%327
5
Omalizumab13.1%326
6
Montelukast-sodium12.5%312
7
Aspirin11.7%291
8
Tramadol-hydrochloride11.6%290
9
Moxifloxacin-hydrochloride11.4%283
10
Prednisone11.0%275
11
Fluticasone10.9%271
12
Clonazepam10.9%271
13
Rituximab10.8%270
14
Risedronate-sodium10.6%264
15
Beclomethasone10.6%264

Taken alongside

1
Albuterol18.9%471
2
Furosemide10.9%271
3
Prednisolone10.2%253
4
Acetaminophen9.9%247
5
Omeprazole9.5%236
6
Aspirin8.2%205
7
Ipratropium-bromide8.1%203
8
Levothyroxine-sodium7.4%184
9
Tiotropium-bromide7.3%182
10
Montelukast-sodium6.3%158
11
Budesonide6.2%155
12
Cetirizine-hydrochloride5.7%142
13
Folic-acid5.5%137
14
Methylprednisolone4.8%119
15
Hydrocortisone4.6%114

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports aminophylline side effects

55.9% of aminophylline adverse event reports involve female patients and 37.1% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.9%
Male37.1%
Unknown7.0%

Age group

< 24.8%
2–112.5%
12–172.9%
18–6436.1%
65+53.7%

What is aminophylline used for

Conditions and purposes for which patients were taking aminophylline when the adverse event was reported.

Abdominal DiscomfortAcute Coronary SyndromeAcute Respiratory Distress SyndromeAcute Respiratory FailureAdjuvant TherapyAllergic BronchitisAngina PectorisApnoea NeonatalApnoeic AttackAspergillus InfectionAspirin-exacerbated Respiratory DiseaseAsthmaAsthma ProphylaxisAsthmatic CrisisAzotaemia

Showing 15 of 195 indications

Aminophylline brand names and reporting trend

Aminophylline is sold under the brand name Somophyllin.

Brand names

Somophyllin2,387

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking aminophylline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.