OpenClaim

Aminoglutethimide Side Effects

The most commonly reported side effects of aminoglutethimide include diarrhoea, nausea, and pyrexia, based on 28 FDA adverse event reports from 2004 to 2024.

Aminoglutethimide side effects

Percentages show how often each reaction appears relative to total reports for aminoglutethimide.

1
Diarrhoea17.9%5
2
Nausea14.3%4
3
Pyrexia10.7%3
4
Somnolence10.7%3
5
Impaired Healing7.1%2
6
Osteonecrosis7.1%2
7
Primary Sequestrum7.1%2
8
Tooth Extraction7.1%2
9
Computerised Tomogram Abnormal7.1%2
10
Dehydration7.1%2
11
Ventricular Hypokinesia7.1%2
12
Bone Disorder7.1%2
13
Neutropenia7.1%2
14
Off Label Use7.1%2
15
Condition Aggravated3.6%1

These are voluntary reports and do not establish that aminoglutethimide caused these reactions.

Report severity

92.9%Serious26 reports
46.4%Hospitalizations13 reports
17.9%Fatal5 reports

Seriousness is determined by the reporter, not by OpenClaim.

Aminoglutethimide drug interactions

Other drugs that appear in adverse event reports alongside aminoglutethimide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Docetaxel14.3%4
2
Capecitabine14.3%4
3
Thalidomide10.7%3
4
Estramustine-phosphate-sodium10.7%3
5
Ketoconazole10.7%3
6
Bicalutamide7.1%2
7
Pamidronate-disodium7.1%2
8
Cyclophosphamide7.1%2
9
Oseltamivir-phosphate7.1%2
10
Octreotide-acetate7.1%2
11
Cabergoline7.1%2
12
Testosterone3.6%1
13
Stanozolol3.6%1
14
Fluoxymesterone3.6%1
15
Anastrozole3.6%1

Taken alongside

1
Hydrocortisone35.7%10
2
Acetaminophen25.0%7
3
Leuprolide21.4%6
4
Dexamethasone21.4%6
5
Finasteride21.4%6
6
Estropipate17.9%5
7
Zoledronic-acid17.9%5
8
Ketoconazole17.9%5
9
Cyclophosphamide14.3%4
10
Calcitriol14.3%4
11
Famotidine10.7%3
12
Estramustine-phosphate-sodium10.7%3
13
Thalidomide10.7%3
14
Aspirin7.1%2
15
Docetaxel7.1%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports aminoglutethimide side effects

35.7% of aminoglutethimide adverse event reports involve female patients and 60.7% involve male patients. The largest age group is adult at 43%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.7%
Male60.7%
Unknown3.6%

Age group

< 20.0%
2–1117.4%
12–170.0%
18–6443.5%
65+39.1%

What is aminoglutethimide used for

Conditions and purposes for which patients were taking aminoglutethimide when the adverse event was reported.

Cushing's SyndromeDisease RecurrenceEctopic Acth SyndromeHypercorticoidismNutritional SupplementationPituitary Tumour BenignPituitary-dependent Cushing's SyndromeProduct Used For Unknown IndicationPrimary HyperaldosteronismProduct Used For Unknown IndicationPyrexiaTuberculosis

Aminoglutethimide brand names and reporting trend

Aminoglutethimide is sold under the brand name Cytadren.

Brand names

Cytadren21

Quarterly reports (20042024)

20042024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking aminoglutethimide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.