OpenClaim

Amiloride Side Effects

The most commonly reported side effects of amiloride include diarrhoea, nausea, and fatigue, based on 6,129 FDA adverse event reports from 2004 to 2025. 3.7% of reports found the drug to be ineffective.

Amiloride side effects

Percentages show how often each reaction appears relative to total reports for amiloride.

1
Diarrhoea4.1%250
2
Nausea3.8%233
3
Drug Ineffective3.7%224
4
Fatigue3.5%215
5
Acute Kidney Injury3.5%212
6
Dyspnoea3.4%211
7
Hyponatraemia3.1%189
8
Asthenia3.1%189
9
Headache3.0%183
10
Vomiting3.0%182
11
Off Label Use2.9%178
12
Drug Interaction2.6%162
13
Malaise2.6%162
14
Pain2.5%156
15
Dizziness2.5%154

These are voluntary reports and do not establish that amiloride caused these reactions.

Report severity

87.2%Serious5,346 reports
50.9%Hospitalizations3,117 reports
9.1%Fatal560 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amiloride drug interactions

Other drugs that appear in adverse event reports alongside amiloride. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Hydrochlorothiazide12.2%749
2
Furosemide2.8%172
3
Lenalidomide2.8%170
4
Metformin2.6%161
5
Amlodipine2.5%156
6
Adalimumab2.4%148
7
Spironolactone1.7%103
8
Aspirin1.6%97
9
Omeprazole1.5%89
10
Valsartan1.5%89
11
Cyclophosphamide1.4%87
12
Atorvastatin-calcium1.4%85
13
Dexamethasone1.3%81
14
Pregabalin1.2%75
15
Ramipril1.2%73

Taken alongside

1
Hydrochlorothiazide36.3%2,226
2
Furosemide16.3%1,000
3
Aspirin15.2%934
4
Acetaminophen13.4%822
5
Omeprazole11.7%718
6
Levothyroxine-sodium11.6%712
7
Atorvastatin-calcium10.1%618
8
Amlodipine9.5%582
9
Ergocalciferol8.9%545
10
Potassium-chloride8.5%521
11
Metformin7.9%483
12
Metoprolol7.9%482
13
Pantoprazole-sodium7.8%478
14
Albuterol7.3%448
15
Simvastatin7.0%428

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amiloride side effects

60.0% of amiloride adverse event reports involve female patients and 33.7% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.0%
Male33.7%
Unknown6.2%

Age group

< 20.4%
2–111.1%
12–170.8%
18–6437.5%
65+60.2%

What is amiloride used for

Conditions and purposes for which patients were taking amiloride when the adverse event was reported.

Abdominal DistensionAllogenic Stem Cell TransplantationAnaphylactic ShockAortic StenosisApparent Mineralocorticoid ExcessArrhythmiaAscitesAtrial FibrillationAutoimmune ThrombocytopeniaAccidental Exposure To Product By ChildAdverse Drug ReactionAntipsychotic TherapyAscitesAtrial FibrillationBartter^s Syndrome

Showing 15 of 193 indications

Amiloride brand names and reporting trend

Amiloride is sold under the brand name Amiloride Hydrochloride And Hydrochlorothiazide.

Brand names

Amiloride Hydrochloride And Hydrochlorothiazide90

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amiloride with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.