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Amifostine Side Effects

The most commonly reported side effects of amifostine include pyrexia, nausea, and hypotension, based on 805 FDA adverse event reports from 2004 to 2025.

Amifostine side effects

Percentages show how often each reaction appears relative to total reports for amifostine.

1
Pyrexia16.4%132
2
Nausea11.4%92
3
Hypotension10.9%88
4
Vomiting9.9%80
5
Dehydration8.0%64
6
Chills7.5%60
7
Mucosal Inflammation6.7%54
8
Rash6.3%51
9
Pruritus5.8%47
10
Rash Generalised5.5%44
11
Dyspnoea4.7%38
12
Pharyngolaryngeal Pain4.6%37
13
Injection Site Erythema4.5%36
14
Malaise4.5%36
15
Nausea4.5%36

These are voluntary reports and do not establish that amifostine caused these reactions.

Report severity

92.8%Serious747 reports
54.8%Hospitalizations441 reports
11.4%Fatal92 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amifostine drug interactions

Other drugs that appear in adverse event reports alongside amifostine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Melphalan6.6%53
2
Cisplatin5.3%43
3
Carboplatin4.8%39
4
Etoposide4.7%38
5
Rituximab4.2%34
6
Paclitaxel3.9%31
7
Cyclophosphamide3.2%26
8
Bevacizumab3.1%25
9
Dexamethasone3.0%24
10
Cytarabine3.0%24
11
Bendamustine-hydrochloride2.9%23
12
Gemcitabine2.6%21
13
Ibritumomab-tiuxetan2.6%21
14
Cetuximab2.0%16
15
Doxorubicin-hydrochloride1.7%14

Taken alongside

1
Cisplatin19.0%153
2
Dexamethasone15.8%127
3
Ondansetron12.0%97
4
Acetaminophen11.4%92
5
Prochlorperazine9.9%80
6
Carboplatin8.8%71
7
Lorazepam8.3%67
8
Paclitaxel8.0%64
9
Diphenhydramine7.2%58
10
Fluorouracil6.7%54
11
Omeprazole6.0%48
12
Granisetron5.5%44
13
Palonosetron-hydrochloride5.3%43
14
Potassium-chloride5.2%42
15
Fluconazole5.0%40

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amifostine side effects

35.4% of amifostine adverse event reports involve female patients and 56.6% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.4%
Male56.6%
Unknown8.0%

Age group

< 20.0%
2–111.8%
12–171.3%
18–6467.9%
65+28.9%

What is amifostine used for

Conditions and purposes for which patients were taking amifostine when the adverse event was reported.

AdenocarcinomaAdjuvant TherapyAdverse Drug ReactionAllogenic Bone Marrow Transplantation TherapyAmyloidosisAntioxidant TherapyAptyalismAcute Myeloid LeukaemiaAdnexa Uteri MassBone Marrow Conditioning RegimenBone NeoplasmBone Neoplasm MalignantBreast CancerBreast CancerCervix Carcinoma

Showing 15 of 93 indications

Amifostine brand names and reporting trend

Amifostine is sold under the brand name Ethyol.

Brand names

Ethyol380

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amifostine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.