OpenClaim

Ambrisentan Side Effects

The most commonly reported side effects of ambrisentan include dyspnoea, headache, and death, based on 124,863 FDA adverse event reports from 2007 to 2025.

Ambrisentan side effects

Percentages show how often each reaction appears relative to total reports for ambrisentan.

1
Dyspnoea14.7%18,294
2
Headache8.5%10,594
3
Death8.0%10,042
4
Diarrhoea5.6%6,950
5
Pneumonia5.3%6,558
6
Nausea5.1%6,407
7
Fatigue5.1%6,387
8
Dizziness5.1%6,353
9
Fluid Retention4.2%5,301
10
Malaise4.2%5,215
11
Cough3.6%4,470
12
Peripheral Swelling3.2%4,053
13
Oedema Peripheral3.1%3,928
14
Nasal Congestion3.0%3,751
15
Chest Pain2.9%3,632

These are voluntary reports and do not establish that ambrisentan caused these reactions.

Report severity

64.8%Serious80,963 reports
42.3%Hospitalizations52,872 reports
13.8%Fatal17,182 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ambrisentan drug interactions

Other drugs that appear in adverse event reports alongside ambrisentan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Treprostinil18.2%22,767
2
Tadalafil5.7%7,172
3
Selexipag4.1%5,069
4
Riociguat2.7%3,417
5
Epoprostenol-sodium2.6%3,214
6
Sildenafil-citrate2.1%2,674
7
Warfarin0.7%880
8
Iloprost0.6%714
9
Sotatercept-csrk0.5%636
10
Macitentan0.5%593
11
Furosemide0.4%442
12
Acetaminophen0.3%319
13
Bosentan0.2%305
14
Rivaroxaban0.2%262
15
Apixaban0.2%253

Taken alongside

1
Tadalafil18.5%23,045
2
Sildenafil-citrate15.2%18,924
3
Treprostinil9.5%11,814
4
Warfarin9.4%11,723
5
Furosemide9.0%11,267
6
Spironolactone4.2%5,187
7
Oxygen4.1%5,072
8
Aspirin3.8%4,803
9
Albuterol3.5%4,328
10
Acetaminophen3.4%4,253
11
Potassium-chloride3.3%4,065
12
Riociguat3.1%3,867
13
Levothyroxine-sodium3.1%3,809
14
Omeprazole3.0%3,734
15
Amlodipine2.9%3,604

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ambrisentan side effects

74.4% of ambrisentan adverse event reports involve female patients and 23.8% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female74.4%
Male23.8%
Unknown1.8%

Age group

< 20.1%
2–111.6%
12–171.4%
18–6453.6%
65+43.3%

What is ambrisentan used for

Conditions and purposes for which patients were taking ambrisentan when the adverse event was reported.

Abdominal DistensionAbdominal InfectionAcquired Immunodeficiency SyndromeAcute Myocardial InfarctionAcute Respiratory Distress SyndromeAcute Respiratory FailureAdverse Drug ReactionAlagille SyndromeAlcohol AbuseAlcohol UseAlcoholic Liver DiseaseAlpha-1 Anti-trypsin DeficiencyAlveolar Lung DiseaseAlveolar ProteinosisAlveolitis

Showing 15 of 752 indications

Ambrisentan brand names and reporting trend

Ambrisentan is sold under the brand name Ambrisentan.

Brand names

Ambrisentan72,445

Quarterly reports (20072025)

20072010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ambrisentan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.