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Amantadine Side Effects

The most commonly reported side effects of amantadine include fall, hallucination, and fatigue, based on 22,795 FDA adverse event reports from 2004 to 2025. 6.9% of reports found the drug to be ineffective.

Amantadine side effects

Percentages show how often each reaction appears relative to total reports for amantadine.

1
Fall9.5%2,159
2
Drug Ineffective6.9%1,581
3
Hallucination6.9%1,574
4
Fatigue6.1%1,387
5
Dyskinesia5.9%1,336
6
Gait Disturbance5.2%1,180
7
Dizziness5.0%1,132
8
Death4.7%1,074
9
Tremor4.5%1,020
10
Nausea3.7%848
11
Parkinson^s Disease3.7%846
12
Asthenia3.5%800
13
Balance Disorder3.4%768
14
Urinary Tract Infection3.3%756
15
Off Label Use3.3%752

These are voluntary reports and do not establish that amantadine caused these reactions.

Report severity

65.0%Serious14,823 reports
33.9%Hospitalizations7,717 reports
11.0%Fatal2,505 reports

Seriousness is determined by the reporter, not by OpenClaim.

Amantadine drug interactions

Other drugs that appear in adverse event reports alongside amantadine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levodopa17.5%4,000
2
Carbidopa14.7%3,356
3
Pimavanserin7.8%1,787
4
Dalfampridine6.4%1,456
5
Interferon5.0%1,145
6
Dimethyl3.8%861
7
Pramipexole-dihydrochloride2.9%663
8
Apomorphine-hydrochloride2.8%643
9
Fingolimod2.7%613
10
Entacapone2.6%600
11
Istradefylline2.6%597
12
Ropinirole-hydrochloride2.2%502
13
Natalizumab2.1%488
14
Quetiapine-fumarate1.9%440
15
Rotigotine1.8%406

Taken alongside

1
Levodopa26.5%6,046
2
Carbidopa26.0%5,926
3
Ergocalciferol15.3%3,496
4
Gabapentin12.7%2,893
5
Aspirin11.4%2,606
6
Baclofen10.9%2,484
7
Acetaminophen10.3%2,350
8
Levothyroxine-sodium9.7%2,205
9
Clonazepam8.9%2,022
10
Omeprazole8.4%1,907
11
Atorvastatin-calcium8.3%1,898
12
Pramipexole-dihydrochloride6.9%1,567
13
Entacapone6.4%1,464
14
Cyanocobalamin6.3%1,446
15
Ropinirole-hydrochloride6.3%1,428

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports amantadine side effects

53.0% of amantadine adverse event reports involve female patients and 40.4% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.0%
Male40.4%
Unknown6.6%

Age group

< 20.1%
2–110.7%
12–170.9%
18–6446.0%
65+52.3%

What is amantadine used for

Conditions and purposes for which patients were taking amantadine when the adverse event was reported.

AbuliaAccidentAccidental ExposureAdjuvant TherapyAdverse Drug ReactionAdverse EventAggressionAgitationAkathisiaAltered State Of ConsciousnessAmnesiaAnorgasmiaAnoxiaAntidepressant TherapyAntifungal Prophylaxis

Showing 15 of 463 indications

Amantadine brand names and reporting trend

Amantadine is sold under brand names including Amantadine, Symadine.

Brand names

Amantadine19,235
Symadine307

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking amantadine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.