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Alvimopan Side Effects

The most commonly reported side effects of alvimopan include hospitalisation, no adverse event, and myocardial infarction, based on 273 FDA adverse event reports from 2006 to 2025.

Alvimopan side effects

Percentages show how often each reaction appears relative to total reports for alvimopan.

1
Hospitalisation7.0%19
2
No Adverse Event6.2%17
3
Myocardial Infarction5.1%14
4
Nausea4.4%12
5
Acute Myocardial Infarction3.3%9
6
Abdominal Pain3.3%9
7
Anastomotic Leak2.9%8
8
Myocardial Infarction2.9%8
9
Dyspnoea2.6%7
10
Small Intestinal Obstruction2.2%6
11
Tachycardia2.2%6
12
Postoperative Ileus2.2%6
13
Vomiting2.2%6
14
Respiratory Failure2.2%6
15
Dysphagia2.2%6

These are voluntary reports and do not establish that alvimopan caused these reactions.

Report severity

71.1%Serious194 reports
45.8%Hospitalizations125 reports
10.3%Fatal28 reports

Seriousness is determined by the reporter, not by OpenClaim.

Alvimopan drug interactions

Other drugs that appear in adverse event reports alongside alvimopan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bupivacaine8.1%22
2
Acetaminophen1.5%4
3
Lidocaine1.1%3
4
Esomeprazole0.7%2
5
Omeprazole0.7%2
6
Pantoprazole-sodium0.7%2
7
Hydrocodone0.4%1
8
Chlordiazepoxide0.4%1
9
Pregabalin0.4%1
10
Ferrous-sulfate0.4%1
11
Alprazolam0.4%1
12
Lisinopril0.4%1
13
Certolizumab-pegol0.4%1
14
Loratadine0.4%1
15
Apomorphine-hydrochloride0.4%1

Taken alongside

1
Acetaminophen16.8%46
2
Heparin11.7%32
3
Ketorolac-tromethamine10.3%28
4
Gabapentin8.8%24
5
Enoxaparin-sodium8.1%22
6
Metoprolol7.7%21
7
Ibuprofen7.7%21
8
Magnesium-acetate-tetrahydrate7.3%20
9
Ammonium7.3%20
10
Hydromorphone-hydrochloride6.6%18
11
Ondansetron5.9%16
12
Oxycodone5.5%15
13
Apomorphine-hydrochloride5.1%14
14
Aspirin4.4%12
15
Metoclopramide-hydrochloride4.0%11

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports alvimopan side effects

33.3% of alvimopan adverse event reports involve female patients and 38.1% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.3%
Male38.1%
Unknown28.6%

Age group

< 20.0%
2–110.0%
12–170.6%
18–6449.4%
65+50.0%

What is alvimopan used for

Conditions and purposes for which patients were taking alvimopan when the adverse event was reported.

Acute Myocardial InfarctionAnaesthetic ComplicationAtrial FibrillationColectomyColectomy TotalColon OperationColostomyConstipationCrest SyndromeColectomyCystoprostatectomyDrug Use For Unknown IndicationGastrointestinal DisorderGastrointestinal SurgeryHysterectomy

Showing 15 of 34 indications

Alvimopan brand names and reporting trend

Alvimopan is sold under the brand name Alvimopan.

Brand names

Alvimopan57

Quarterly reports (20062025)

20062010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking alvimopan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.