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Alprazolam Side Effects

The most commonly reported side effects of alprazolam include drug abuse, fatigue, and nausea, based on 206,063 FDA adverse event reports from 2004 to 2025. 5.4% of reports found the drug to be ineffective.

Alprazolam side effects

Percentages show how often each reaction appears relative to total reports for alprazolam.

1
Drug Ineffective5.4%11,077
2
Drug Abuse5.2%10,774
3
Fatigue4.8%9,842
4
Nausea4.7%9,652
5
Toxicity To Various Agents4.3%8,884
6
Headache3.8%7,826
7
Pain3.7%7,652
8
Diarrhoea3.5%7,290
9
Anxiety3.5%7,278
10
Off Label Use3.3%6,832
11
Dyspnoea3.0%6,151
12
Death2.9%5,930
13
Dizziness2.8%5,713
14
Completed Suicide2.7%5,604
15
Fall2.7%5,514

These are voluntary reports and do not establish that alprazolam caused these reactions.

Report severity

70.7%Serious145,607 reports
31.8%Hospitalizations65,570 reports
16.6%Fatal34,252 reports

Seriousness is determined by the reporter, not by OpenClaim.

Alprazolam drug interactions

Other drugs that appear in adverse event reports alongside alprazolam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxycodone4.5%9,262
2
Acetaminophen4.2%8,691
3
Adalimumab3.5%7,164
4
Quetiapine-fumarate3.2%6,506
5
Pregabalin2.6%5,396
6
Fentanyl2.6%5,351
7
Lenalidomide2.5%5,224
8
Sodium-oxybate2.4%4,861
9
Omeprazole2.1%4,256
10
Hydrocodone2.1%4,243
11
Diazepam2.0%4,159
12
Zolpidem-tartrate2.0%4,019
13
Pantoprazole-sodium1.9%3,948
14
Tramadol-hydrochloride1.9%3,896
15
Esomeprazole1.9%3,889

Taken alongside

1
Acetaminophen16.1%33,198
2
Aspirin11.0%22,615
3
Levothyroxine-sodium10.7%21,946
4
Ergocalciferol10.0%20,607
5
Omeprazole9.4%19,381
6
Albuterol8.7%17,955
7
Gabapentin8.7%17,925
8
Furosemide8.1%16,781
9
Hydrocodone7.9%16,256
10
Oxycodone7.8%16,052
11
Atorvastatin-calcium7.1%14,731
12
Metoprolol7.1%14,561
13
Amlodipine6.6%13,692
14
Lisinopril6.5%13,371
15
Zolpidem-tartrate6.4%13,115

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports alprazolam side effects

63.8% of alprazolam adverse event reports involve female patients and 30.5% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.8%
Male30.5%
Unknown5.7%

Age group

< 20.4%
2–110.2%
12–171.3%
18–6467.4%
65+30.7%

What is alprazolam used for

Conditions and purposes for which patients were taking alprazolam when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain UpperAbnormal BehaviourAbnormal DreamsAccident At WorkAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental OverdoseAcrophobiaAcute Coronary SyndromeAcute PsychosisAcute Stress Disorder

Showing 15 of 1,219 indications

Alprazolam brand names and reporting trend

Alprazolam is sold under the brand name Niravam.

Brand names

Niravam124,114

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking alprazolam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.