OpenClaim

Alglucosidase Side Effects

The most commonly reported side effects of alglucosidase include pyrexia, dyspnoea, and off label use, based on 4,583 FDA adverse event reports from 2006 to 2025.

#1 Reported: PyrexiaAll side effects ↓Top Co-Medication: MethotrexateDrug interactions ↓43% of Reports Are AdultDemographics ↓

Alglucosidase side effects

Percentages show how often each reaction appears relative to total reports for alglucosidase.

1
Pyrexia6.8%310
2
Dyspnoea5.3%245
3
Off Label Use5.0%230
4
Pneumonia4.8%222
5
Inappropriate Schedule Of Product Administration4.4%201
6
Death3.5%162
7
Respiratory Failure3.3%150
8
Malaise3.1%143
9
Fatigue2.9%135
10
Disease Progression2.8%129
11
Respiratory Failure2.7%124
12
Fall2.7%124
13
Asthenia2.5%114
14
Oxygen Saturation Decreased2.5%113
15
Rash2.4%112

These are voluntary reports and do not establish that alglucosidase caused these reactions.

Report severity

64.3%Serious2,949 reports
31.0%Hospitalizations1,423 reports
20.3%Fatal932 reports

Seriousness is determined by the reporter, not by OpenClaim.

Alglucosidase drug interactions

Other drugs that appear in adverse event reports alongside alglucosidase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate1.5%68
2
Rituximab1.3%61
3
Diphenhydramine0.3%16
4
Pantoprazole-sodium0.2%10
5
Agalsidase-beta0.2%9
6
Bortezomib0.2%9
7
Dexamethasone0.2%8
8
Propranolol-hydrochloride0.2%7
9
Ramipril0.1%6
10
Miglustat0.1%6
11
Avalglucosidase-alfa-ngpt0.1%6
12
Meropenem0.1%6
13
Cetirizine-hydrochloride0.1%6
14
Acetaminophen0.1%5
15
Diclofenac0.1%5

Taken alongside

1
Diphenhydramine8.3%381
2
Acetaminophen7.3%335
3
Sodium-chloride4.6%213
4
Epinephrine4.4%202
5
Sterile3.6%167
6
Heparin3.5%159
7
Albuterol3.2%146
8
Furosemide3.1%142
9
Ibuprofen2.7%125
10
Ergocalciferol2.6%119
11
Methylprednisolone2.6%117
12
Cetirizine-hydrochloride2.2%100
13
Lidocaine1.8%82
14
Hydrocortisone1.7%79
15
Aspirin1.6%72

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports alglucosidase side effects

43.6% of alglucosidase adverse event reports involve female patients and 43.1% involve male patients. The largest age group is adult at 43%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.6%
Male43.1%
Unknown13.3%

Age group

< 220.3%
2–1122.9%
12–175.8%
18–6443.0%
65+8.0%

What is alglucosidase used for

Conditions and purposes for which patients were taking alglucosidase when the adverse event was reported.

Accidental Exposure To ProductComplement Deficiency DiseaseCystic FibrosisCardiac FailureComplement Deficiency DiseaseDiabetes MellitusEnzyme AbnormalityEczemaFabry's DiseaseFabry^s DiseaseGaucher^s DiseaseGaucher^s Disease Type IiiGene MutationGlycogen Storage Disease Type IGlycogen Storage Disease Type Ii

Showing 15 of 33 indications

Alglucosidase brand names and reporting trend

Alglucosidase is sold under the brand name Myozyme.

Brand names

Myozyme741

Quarterly reports (2006–2025)

20062010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking alglucosidase with another medication?

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