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Alectinib Side Effects

The most commonly reported side effects of alectinib include death, fatigue, and constipation, based on 9,586 FDA adverse event reports from 2009 to 2025. 3.1% of reports found the drug to be ineffective.

Alectinib side effects

Percentages show how often each reaction appears relative to total reports for alectinib.

1
Death7.7%739
2
Fatigue6.6%637
3
Constipation5.7%545
4
Off Label Use5.5%529
5
No Adverse Event5.2%498
6
Disease Progression4.0%379
7
Rash3.4%324
8
Dyspnoea3.2%304
9
Drug Ineffective3.1%297
10
Anaemia2.9%277
11
Myalgia2.9%276
12
Asthenia2.8%271
13
Nausea2.6%252
14
Weight Increased2.6%246
15
Diarrhoea2.4%227

These are voluntary reports and do not establish that alectinib caused these reactions.

Report severity

54.4%Serious5,217 reports
17.2%Hospitalizations1,653 reports
11.7%Fatal1,121 reports

Seriousness is determined by the reporter, not by OpenClaim.

Alectinib drug interactions

Other drugs that appear in adverse event reports alongside alectinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Crizotinib2.8%265
2
Lorlatinib2.3%220
3
Bevacizumab1.6%151
4
Carboplatin1.4%132
5
Brigatinib1.4%131
6
Ceritinib1.3%123
7
Pemetrexed1.2%113
8
Paclitaxel0.8%74
9
Pantoprazole-sodium0.7%67
10
Cisplatin0.6%58
11
Atezolizumab0.6%53
12
Rosuvastatin0.5%47
13
Pembrolizumab0.4%43
14
Denosumab0.4%38
15
Levetiracetam0.4%38

Taken alongside

1
Acetaminophen3.1%297
2
Dexamethasone2.8%272
3
Lorlatinib2.6%247
4
Pantoprazole-sodium2.3%223
5
Levothyroxine-sodium2.3%219
6
Furosemide2.2%214
7
Omeprazole2.1%201
8
Aspirin2.1%199
9
Atorvastatin-calcium1.9%181
10
Ondansetron1.8%172
11
Apixaban1.8%171
12
Crizotinib1.8%169
13
Metformin1.7%166
14
Folic-acid1.7%161
15
Amlodipine1.6%157

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports alectinib side effects

54.1% of alectinib adverse event reports involve female patients and 36.6% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.1%
Male36.6%
Unknown9.3%

Age group

< 20.2%
2–110.4%
12–170.3%
18–6457.3%
65+41.7%

What is alectinib used for

Conditions and purposes for which patients were taking alectinib when the adverse event was reported.

Acute Left Ventricular FailureAdenocarcinomaAdenocarcinoma MetastaticAdenosquamous Cell CarcinomaAgranulocytosisAlk Gene Rearrangement PositiveAlk Gene Rearrangement PositiveAnaemiaAnaplastic Large-cell LymphomaAnaplastic Lymphoma Kinase Gene MutationAtrial FibrillationAbdominal DistensionAbdominal Pain UpperAcute Myeloid LeukaemiaAcute Respiratory Failure

Showing 15 of 429 indications

Alectinib brand names and reporting trend

Alectinib is sold under the brand name Alecensa.

Brand names

Alecensa3,586

Quarterly reports (20092025)

20092016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking alectinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.