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Alcaftadine Side Effects

The most commonly reported side effects of alcaftadine include ocular hyperaemia, eye irritation, and eye pruritus, based on 897 FDA adverse event reports from 2011 to 2025. 6.5% of reports found the drug to be ineffective.

Alcaftadine side effects

Percentages show how often each reaction appears relative to total reports for alcaftadine.

1
Ocular Hyperaemia25.3%227
2
Eye Irritation14.4%129
3
Eye Pruritus8.9%80
4
Eye Pain8.8%79
5
Ocular Hyperaemia7.7%69
6
Eye Swelling7.0%63
7
Hypersensitivity6.5%58
8
Drug Ineffective6.5%58
9
Lacrimation Increased5.2%47
10
Eye Irritation4.3%39
11
Off Label Use4.0%36
12
Eye Discharge4.0%36
13
Headache3.8%34
14
Conjunctivitis3.8%34
15
Eyelid Oedema3.7%33

These are voluntary reports and do not establish that alcaftadine caused these reactions.

Report severity

14.9%Serious134 reports
3.9%Hospitalizations35 reports
0.8%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Alcaftadine drug interactions

Other drugs that appear in adverse event reports alongside alcaftadine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate2.9%26
2
Olopatadine-hydrochloride2.7%24
3
Cyclosporine1.4%13
4
Azelastine1.4%13
5
Lenalidomide1.2%11
6
Adalimumab1.1%10
7
Ketotifen-fumarate1.1%10
8
Loteprednol-etabonate1.0%9
9
Omalizumab0.8%7
10
Epinastine-hydrochloride0.8%7
11
Dupilumab0.7%6
12
Calcium-oxybate0.7%6
13
Magnesium-oxybate0.7%6
14
Potassium-oxybate0.7%6
15
Tobramycin0.6%5

Taken alongside

1
Ergocalciferol6.7%60
2
Fluticasone6.0%54
3
Levothyroxine-sodium5.9%53
4
Albuterol5.8%52
5
Montelukast-sodium5.0%45
6
Acetaminophen4.7%42
7
Omeprazole4.2%38
8
Aspirin3.8%34
9
Cyclosporine3.6%32
10
Cetirizine-hydrochloride3.6%32
11
Olopatadine-hydrochloride3.0%27
12
Atorvastatin-calcium3.0%27
13
Cyanocobalamin2.9%26
14
Triamcinolone2.9%26
15
Ibuprofen2.8%25

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports alcaftadine side effects

73.7% of alcaftadine adverse event reports involve female patients and 19.7% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female73.7%
Male19.7%
Unknown6.6%

Age group

< 20.2%
2–111.9%
12–171.3%
18–6462.8%
65+33.8%

What is alcaftadine used for

Conditions and purposes for which patients were taking alcaftadine when the adverse event was reported.

Allergic ConjunctivitisAllergic SinusitisAllergy NosAntiallergic TherapyAsthenopiaAllergy ProphylaxisBlepharitisBlepharitisCataract OperationConjunctivitisConjunctivitis AllergicConjunctivitis ViralCryingConjunctivitisConjunctivitis Allergic

Showing 15 of 72 indications

Alcaftadine brand names and reporting trend

Alcaftadine is sold under the brand name Lastacaft.

Brand names

Lastacaft20

Quarterly reports (20112025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking alcaftadine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.