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Adenosine Side Effects

The most commonly reported side effects of adenosine include off label use, dyspnoea, and supraventricular tachycardia, based on 2,846 FDA adverse event reports from 2004 to 2025. 12.5% of reports found the drug to be ineffective.

Adenosine side effects

Percentages show how often each reaction appears relative to total reports for adenosine.

1
Drug Ineffective12.5%357
2
Off Label Use5.6%160
3
Dyspnoea2.7%78
4
Supraventricular Tachycardia2.7%77
5
Hypotension2.4%69
6
Cardiac Arrest2.3%65
7
Product Use In Unapproved Indication2.3%65
8
Pain2.1%60
9
Anxiety2.0%57
10
Dyspnoea1.9%54
11
Tachycardia1.9%54
12
Nausea1.9%53
13
Pyrexia1.9%53
14
Bradycardia1.8%50
15
Atrial Fibrillation1.7%49

These are voluntary reports and do not establish that adenosine caused these reactions.

Report severity

88.9%Serious2,530 reports
43.0%Hospitalizations1,224 reports
13.8%Fatal393 reports

Seriousness is determined by the reporter, not by OpenClaim.

Adenosine drug interactions

Other drugs that appear in adverse event reports alongside adenosine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Amiodarone-hydrochloride9.2%261
2
Metoprolol5.4%154
3
Diltiazem2.9%83
4
Tacrolimus2.9%82
5
Digoxin2.7%77
6
Verapamil-hydrochloride2.6%75
7
Flecainide-acetate2.5%71
8
Sodium-oxybate2.3%65
9
Prednisone2.2%62
10
Propranolol-hydrochloride2.1%59
11
Dexamethasone2.0%58
12
Prednisolone1.8%52
13
Cyclosporine1.8%51
14
Methylprednisolone1.8%50
15
Mycophenolate1.7%49

Taken alongside

1
Aspirin10.8%308
2
Acetaminophen10.3%294
3
Furosemide9.8%278
4
Metoprolol7.0%200
5
Amlodipine6.7%192
6
Omeprazole6.5%184
7
Atorvastatin-calcium6.3%178
8
Prednisone6.2%176
9
Heparin5.7%163
10
Methylprednisolone5.7%161
11
Insulin5.4%153
12
Albuterol5.3%151
13
Amiodarone-hydrochloride5.0%141
14
Metformin4.8%136
15
Levothyroxine-sodium4.8%136

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports adenosine side effects

42.2% of adenosine adverse event reports involve female patients and 46.7% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.2%
Male46.7%
Unknown11.1%

Age group

< 26.9%
2–112.1%
12–172.9%
18–6453.6%
65+34.4%

What is adenosine used for

Conditions and purposes for which patients were taking adenosine when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAccelerated Idioventricular RhythmAccessory Cardiac PathwayAcquired Immunodeficiency SyndromeAcute Myocardial InfarctionAdenosine DeaminaseAdverse EventAlternating Hemiplegia Of ChildhoodAnalgesic TherapyAneurysm RepairAngina PectorisAngiogramAntiplatelet TherapyAntiviral Prophylaxis

Showing 15 of 304 indications

Adenosine brand names and reporting trend

Adenosine is sold under the brand name Adenocard.

Brand names

Adenocard3,080

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking adenosine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.