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Adefovir Side Effects

The most commonly reported side effects of adefovir include drug resistance, osteomalacia, and hypophosphataemia, based on 3,829 FDA adverse event reports from 2004 to 2025. 6.2% of reports found the drug to be ineffective.

Adefovir side effects

Percentages show how often each reaction appears relative to total reports for adefovir.

1
Drug Resistance15.5%592
2
Osteomalacia12.8%491
3
Hypophosphataemia11.6%444
4
Fanconi Syndrome Acquired9.3%358
5
Osteoporosis6.7%256
6
Renal Impairment6.6%251
7
Bone Pain6.3%241
8
Drug Ineffective6.2%238
9
Pathogen Resistance6.1%234
10
Arthralgia5.7%218
11
Blood Phosphorus Decreased4.9%187
12
Blood Alkaline Phosphatase Increased4.7%179
13
Viral Mutation Identified4.5%173
14
Fanconi Syndrome4.4%167
15
Blood Creatinine Increased4.1%158

These are voluntary reports and do not establish that adefovir caused these reactions.

Report severity

96.3%Serious3,687 reports
33.1%Hospitalizations1,266 reports
6.6%Fatal253 reports

Seriousness is determined by the reporter, not by OpenClaim.

Adefovir drug interactions

Other drugs that appear in adverse event reports alongside adefovir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lamivudine24.4%934
2
Tenofovir17.0%652
3
Entecavir12.5%480
4
Telbivudine3.2%122
5
Tacrolimus1.3%49
6
Sorafenib-tosylate1.2%47
7
Emtricitabine1.1%44
8
Mycophenolate1.1%42
9
Ritonavir0.9%34
10
Cyclosporine0.8%29
11
Prednisone0.8%29
12
Prednisolone0.7%28
13
Zidovudine0.7%25
14
Rituximab0.5%20
15
Ropeginterferon-alfa-2b-njft0.5%20

Taken alongside

1
Lamivudine8.1%311
2
Entecavir6.8%259
3
Furosemide2.6%99
4
Tenofovir2.2%86
5
Spironolactone2.1%81
6
Aspirin1.4%54
7
Omeprazole1.2%47
8
Amlodipine1.2%47
9
Insulin1.2%46
10
Taurursodiol1.1%44
11
Ergocalciferol1.1%43
12
Prednisone1.0%40
13
Deoxycholic-acid1.0%40
14
Ursodiol1.0%38
15
Famotidine0.9%34

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports adefovir side effects

23.0% of adefovir adverse event reports involve female patients and 60.5% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female23.0%
Male60.5%
Unknown16.6%

Age group

< 20.3%
2–110.2%
12–170.3%
18–6479.0%
65+20.1%

What is adefovir used for

Conditions and purposes for which patients were taking adefovir when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hepatitis BAlanine Aminotransferase IncreasedAnti-infective TherapyAntiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAnti-infective TherapyAntiviral TreatmentCaesarean SectionChemotherapyChronic HepatitisChronic Hepatitis BChronic Hepatitis CCirrhosis Alcoholic

Showing 15 of 70 indications

Adefovir brand names and reporting trend

Adefovir is sold under the brand name Hepsera.

Brand names

Hepsera2,106

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking adefovir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.