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Adagrasib Side Effects

The most commonly reported side effects of adagrasib include death, diarrhoea, and hospitalisation, based on 958 FDA adverse event reports from 2021 to 2025.

Adagrasib side effects

Percentages show how often each reaction appears relative to total reports for adagrasib.

1
Death29.2%280
2
Diarrhoea12.1%116
3
Hospitalisation11.3%108
4
Nausea9.5%91
5
Vomiting8.8%84
6
Off Label Use7.9%76
7
Asthenia6.5%62
8
Fatigue5.4%52
9
Decreased Appetite4.5%43
10
Dehydration3.7%35
11
Dyspnoea3.5%34
12
Acute Kidney Injury2.9%28
13
Dizziness2.8%27
14
Weight Decreased2.5%24
15
Drug Interaction2.1%20

These are voluntary reports and do not establish that adagrasib caused these reactions.

Report severity

80.2%Serious768 reports
38.2%Hospitalizations366 reports
33.8%Fatal324 reports

Seriousness is determined by the reporter, not by OpenClaim.

Adagrasib drug interactions

Other drugs that appear in adverse event reports alongside adagrasib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pembrolizumab4.3%41
2
Cetuximab4.2%40
3
Sotorasib1.4%13
4
Carboplatin1.1%11
5
Apixaban0.7%7
6
Denosumab0.7%7
7
Bevacizumab0.7%7
8
Pemetrexed0.7%7
9
Pravastatin-sodium0.7%7
10
Amoxicillin0.7%7
11
Furosemide0.7%7
12
Irinotecan-hydrochloride0.6%6
13
Paclitaxel0.6%6
14
Spironolactone0.6%6
15
Fluorouracil0.5%5

Taken alongside

1
Ondansetron6.8%65
2
Acetaminophen6.5%62
3
Atorvastatin-calcium5.3%51
4
Prochlorperazine4.9%47
5
Omeprazole3.7%35
6
Folic-acid3.5%34
7
Oxycodone3.3%32
8
Metoprolol3.1%30
9
Dexamethasone2.9%28
10
Apixaban2.9%28
11
Pantoprazole-sodium2.9%28
12
Prednisone2.8%27
13
Aspirin2.7%26
14
Levothyroxine-sodium2.7%26
15
Ergocalciferol2.6%25

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports adagrasib side effects

42.6% of adagrasib adverse event reports involve female patients and 31.7% involve male patients. The largest age group is elderly at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.6%
Male31.7%
Unknown25.7%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6434.3%
65+65.7%

What is adagrasib used for

Conditions and purposes for which patients were taking adagrasib when the adverse event was reported.

Abdominal NeoplasmAbdominal PainAdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma PancreasAppendix CancerBile Duct CancerBone CancerBrain Neoplasm MalignantBreast CancerBronchial CarcinomaColon CancerChemotherapyCholangiocarcinomaChronic Lymphocytic Leukaemia

Showing 15 of 64 indications

Adagrasib brand names and reporting trend

Adagrasib is sold under the brand name Krazati.

Brand names

Krazati157

Quarterly reports (20212025)

202120242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking adagrasib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.