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Acoltremon Side Effects

The most commonly reported side effects of acoltremon include eye irritation, eye pain, and vision blurred, based on 1,316 FDA adverse event reports from 2010 to 2025. 16.6% of reports found the drug to be ineffective.

Acoltremon side effects

Percentages show how often each reaction appears relative to total reports for acoltremon.

1
Eye Irritation53.7%707
2
Eye Pain20.1%264
3
Drug Ineffective16.6%218
4
Vision Blurred9.3%122
5
Ocular Hyperaemia6.9%91
6
Ocular Discomfort5.4%71
7
Eye Pruritus3.6%48
8
Headache3.3%44
9
Lacrimation Increased3.3%44
10
Dry Eye3.0%40
11
Condition Aggravated2.4%32
12
Dizziness2.1%27
13
Multiple Use Of Single-use Product1.8%24
14
Visual Impairment1.5%20
15
Eye Swelling1.5%20

These are voluntary reports and do not establish that acoltremon caused these reactions.

Report severity

1.9%Serious25 reports
0.6%Hospitalizations8 reports
<0.1%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Acoltremon drug interactions

Other drugs that appear in adverse event reports alongside acoltremon. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclosporine2.5%33
2
Levothyroxine-sodium0.5%7
3
Denosumab0.4%5
4
Perfluorohexyloctane0.4%5
5
Evolocumab0.4%5
6
Ambrisentan0.3%4
7
Tirzepatide0.3%4
8
Loteprednol-etabonate0.2%3
9
Brimonidine-tartrate0.2%3
10
Rosuvastatin0.2%3
11
Apixaban0.2%2
12
Netarsudil0.2%2
13
Prednisolone0.2%2
14
Timolol0.2%2
15
Metoprolol0.2%2

Taken alongside

1
Levothyroxine-sodium8.4%111
2
Rosuvastatin6.3%83
3
Atorvastatin-calcium5.8%76
4
Ergocalciferol5.5%73
5
Omeprazole5.1%67
6
Amlodipine4.9%65
7
Losartan-potassium4.9%65
8
Cyclosporine4.7%62
9
Metoprolol4.6%60
10
Aspirin3.8%50
11
Gabapentin3.3%43
12
Hydrochlorothiazide2.8%37
13
Metformin2.7%36
14
Acetaminophen2.7%35
15
Lisinopril2.5%33

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports acoltremon side effects

81.4% of acoltremon adverse event reports involve female patients and 12.0% involve male patients. The largest age group is elderly at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female81.4%
Male12.0%
Unknown6.6%

Age group

< 20.2%
2–110.0%
12–170.0%
18–6425.5%
65+74.2%

What is acoltremon used for

Conditions and purposes for which patients were taking acoltremon when the adverse event was reported.

AsthmaCorneal DystrophyCorneal ScarDiabetes MellitusDry EyeEye DisorderEye PainEye PruritusHeadacheKeratitisLacrimal DisorderLacrimation DecreasedLacrimation IncreasedMeibomian Gland DysfunctionOpen Angle Glaucoma

Showing 15 of 20 indications

Acoltremon brand names and reporting trend

Acoltremon is sold under the brand name Tryptyr.

Brand names

Tryptyr1,256

Quarterly reports (20102025)

20102025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking acoltremon with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.