OpenClaim

Acetylcholine Side Effects

The most commonly reported side effects of acetylcholine include dyspnoea, cough, and depression, based on 212 FDA adverse event reports from 2004 to 2025.

Acetylcholine side effects

Percentages show how often each reaction appears relative to total reports for acetylcholine.

1
Dyspnoea18.4%39
2
Cough17.9%38
3
Depression17.0%36
4
Rhinorrhoea16.5%35
5
Sinusitis16.5%35
6
Chest Discomfort16.5%35
7
Sleep Disorder Due To A General Medical Condition16.0%34
8
Therapeutic Product Effect Incomplete16.0%34
9
Sleep Disorder16.0%34
10
Pneumonia16.0%34
11
Eosinophilia15.6%33
12
Mental Impairment15.6%33
13
Obstruction15.6%33
14
Anxiety15.6%33
15
Productive Cough15.6%33

These are voluntary reports and do not establish that acetylcholine caused these reactions.

Report severity

81.1%Serious172 reports
33.5%Hospitalizations71 reports
4.2%Fatal9 reports

Seriousness is determined by the reporter, not by OpenClaim.

Acetylcholine drug interactions

Other drugs that appear in adverse event reports alongside acetylcholine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Prednisone16.5%35
2
Budesonide16.0%34
3
Dextromethorphan15.6%33
4
Letrozole15.6%33
5
Acetaminophen15.6%33
6
Hydromorphone-hydrochloride15.6%33
7
Ipratropium-bromide15.6%33
8
Moxifloxacin-hydrochloride15.6%33
9
Fluticasone15.6%33
10
Omeprazole15.6%33
11
Albuterol15.6%33
12
Clonazepam15.6%33
13
Sertraline-hydrochloride15.6%33
14
Lorazepam15.6%33
15
Umeclidinium-bromide15.1%32

Taken alongside

1
Sodium-chloride9.4%20
2
Dexamethasone9.0%19
3
Acetaminophen9.0%19
4
Aspirin8.5%18
5
Calcium-chloride8.0%17
6
Potassium-chloride8.0%17
7
Magnesium-chloride7.5%16
8
Cefazolin-sodium6.1%13
9
Dextrose5.7%12
10
Glutathione-disulfide5.7%12
11
Sodium-bicarbonate5.2%11
12
Sodium-phosphate5.2%11
13
Calcium5.2%11
14
Omeprazole4.7%10
15
Prednisone4.7%10

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports acetylcholine side effects

54.7% of acetylcholine adverse event reports involve female patients and 32.5% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.7%
Male32.5%
Unknown12.7%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6460.0%
65+40.0%

What is acetylcholine used for

Conditions and purposes for which patients were taking acetylcholine when the adverse event was reported.

Adverse EventAsthmaCataractCataract OperationCataract OperationCoronary Artery DiseaseDiagnostic ProcedureDrug TherapyDrug Provocation TestGlaucomaIridectomyMiosisMyasthenia GravisMydriasisMiosis

Showing 15 of 27 indications

Acetylcholine brand names and reporting trend

Acetylcholine is sold under the brand name Miochol-e.

Brand names

Miochol-e123

Quarterly reports (20042025)

2004201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking acetylcholine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.