OpenClaim

Abatacept Side Effects

The most commonly reported side effects of abatacept include rheumatoid arthritis, pain, and arthralgia, based on 133,866 FDA adverse event reports from 2004 to 2025. 28.6% of reports found the drug to be ineffective.

Abatacept side effects

Percentages show how often each reaction appears relative to total reports for abatacept.

1
Drug Ineffective28.6%38,321
2
Rheumatoid Arthritis17.6%23,495
3
Pain15.9%21,233
4
Arthralgia15.0%20,077
5
Joint Swelling14.7%19,672
6
Fatigue10.5%14,071
7
Contraindicated Product Administered10.3%13,792
8
Drug Intolerance9.7%12,989
9
Rash9.6%12,843
10
Off Label Use8.8%11,742
11
Arthropathy8.6%11,546
12
Alopecia7.8%10,482
13
Synovitis7.6%10,146
14
Abdominal Discomfort7.5%10,002
15
Treatment Failure7.2%9,692

These are voluntary reports and do not establish that abatacept caused these reactions.

Report severity

60.9%Serious81,475 reports
18.5%Hospitalizations24,758 reports
6.5%Fatal8,696 reports

Seriousness is determined by the reporter, not by OpenClaim.

Abatacept drug interactions

Other drugs that appear in adverse event reports alongside abatacept. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate28.6%38,245
2
Etanercept27.1%36,218
3
Adalimumab23.4%31,348
4
Tocilizumab22.5%30,181
5
Leflunomide20.8%27,878
6
Hydroxychloroquine-sulfate19.5%26,112
7
Rituximab18.7%25,075
8
Infliximab17.2%23,084
9
Sulfasalazine14.7%19,727
10
Certolizumab-pegol13.2%17,607
11
Golimumab13.1%17,558
12
Prednisone11.3%15,147
13
Tofacitinib10.3%13,816
14
Folic-acid8.3%11,098
15
Alendronate-sodium8.2%11,021

Taken alongside

1
Prednisone11.3%15,092
2
Methotrexate10.2%13,721
3
Tofacitinib8.2%10,935
4
Acetaminophen7.4%9,848
5
Folic-acid6.8%9,126
6
Hydroxychloroquine-sulfate6.6%8,860
7
Pantoprazole-sodium5.7%7,575
8
Leflunomide5.6%7,439
9
Sulfasalazine5.5%7,420
10
Ergocalciferol5.0%6,729
11
Ibuprofen4.5%6,044
12
Levothyroxine-sodium3.2%4,274
13
Calcium2.9%3,878
14
Celecoxib2.6%3,504
15
Adalimumab2.6%3,493

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports abatacept side effects

76.7% of abatacept adverse event reports involve female patients and 13.5% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female76.7%
Male13.5%
Unknown9.9%

Age group

< 20.2%
2–110.7%
12–171.0%
18–6462.2%
65+35.8%

What is abatacept used for

Conditions and purposes for which patients were taking abatacept when the adverse event was reported.

Acute Febrile Neutrophilic DermatosisAcute Graft Versus Host DiseaseAcute Myeloid LeukaemiaAdenocarcinomaAdverse EventAllogenic Stem Cell TransplantationAlopecia AreataAlpha-1 Antitrypsin DeficiencyAnaemiaAngiopathyAnkylosing SpondylitisAntiinflammatory TherapyAntisynthetase SyndromeAplastic AnaemiaArthralgia

Showing 15 of 641 indications

Abatacept brand names and reporting trend

Abatacept is sold under the brand name Orencia.

Brand names

Orencia27,039

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking abatacept with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.